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Malignant hyperthermia: clinical and molecular aspects.

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Acute Aerobic Swimming Exercise Induces Distinct Effects in the Contractile Reactivity of Rat Ileum to KCl and Carbachol

The ileum sensitivity to contractile agents is differentially altered by the acute aerobic swimming exercise, without affecting the oxidative stress and the morphology of ileu smooth muscle.
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Spasmolytic effect of galetin 3,6-dimethyl ether, a flavonoid obtained from Piptadenia stipulacea (Benth) Ducke.

Galetin 3,6-dimethyl ether (FGAL) is a flavonoid isolated from the aerial components of Piptadenia stipulacea (Benth) Ducke that shows a non-selective spasmolytic effect on each of the smooth muscle preparations the authors have tested, but with a greater effect on those from the rat aorta.
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Spirulina platensis prevents oxidative stress and inflammation promoted by strength training in rats: dose-response relation study

Spirulina supplementation for 8 weeks (in a dose-effect manner) improved antioxidant capacity as well as attenuated exercise-induced increases in ROS and inflammation, and the use as high doses did not cause a reduction in positive physiological adaptations to exercise training.
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A Guinea Pig Model of Airway Smooth Muscle Hyperreactivity Induced by Chronic Allergic Lung Inflammation: Contribution of Epithelium and Oxidative Stress

A standardized and easy-to-use, reproducible guinea pig model of lung inflammation that mimics airway smooth muscle hypercontractility is developed, facilitating the investigation of the mechanisms of bronchial hyperresponsiveness in asthma and new therapeutic alternatives.
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Intensity of swimming exercise influences aortic reactivity in rats

Results indicate a reduction in vasorelaxing activity and an increase in contractile activity in rat aortas after high-intensity exercise, followed by a increase in lipid peroxidation.
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Hypercaloric Diet Establishes Erectile Dysfunction in Rat: Mechanisms Underlying the Endothelial Damage

OG was provided a model for advances in sexual dysfunction field and drug discovery for ED treatment and there was a decrease in the number and the latency of penile erections in OG, and the contractile reactivity of corpus cavernosum was increased in OG.
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Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum.

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Chronic aerobic swimming exercise promotes functional and morphological changes in rat ileum

It is shown that, accordingly to the time of exercise, the rat ileum has its contractile reactivity reduced, in addition to the increased lipid peroxidation followed by its reestablishment to basal levels, as well as the augmented longitudinal smooth muscle layer thickness together with the reduced circular thickness.
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Mechanisms Underlying Vasorelaxation Induced in Rat Aorta by Galetin 3,6-Dimethyl Ether, a Flavonoid from Piptadenia stipulacea (Benth.) Ducke

The FGAL vasorelaxant mechanism involves noncompetitive antagonism of α1 adrenergic receptors, the non-selective opening of K+ channels, inhibition of Ca2+ influx through CaV or ROCs and the inhibition of intracellular Ca2+, particularly through PDE V inhibition.
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