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Examination of postmortem fluids and tissues for the presence of methylecgonidine, ecgonidine, cocaine, and benzoylecgonine using solid-phase extraction and gas chromatography-mass spectrometry.
TLDR
The hydrolysis product ED was detected in all postmortem cases, and the concentrations were substantially higher than MED in all liver, blood, and urine specimens. Expand
Concentration profiles of cocaine, pyrolytic methyl ecgonidine and thirteen metabolites in human blood and urine: determination by gas chromatography-mass spectrometry.
TLDR
Ecgonine, the major metabolite of methyl ecgonidine, was present in 77% of PM and 88% of the LV specimens, indicating smoking as the major route of cocaine administration, indicating detection of ecgonine is advantageous when benzoylecgonine concentrations are below 100 ng/mL. Expand
Electron ionization mass fragmentometric detection of urinary ecgonidine, a hydrolytic product of methylecgonidine, as an indicator of smoking cocaine.
TLDR
Ecgonidine was detected in > 95% of benzoylecgonine-positive urine specimens from a random drug testing program, indicating smoking as the major route of cocaine administration. Expand
Urinary excretion profiles for total morphine, free morphine, and 6-acetylmorphine following smoked and intravenous heroin.
TLDR
This study was a comprehensive examination of pharmacokinetics, pharmacodynamics, detection times, opiate immunoassay performance, and urine excretion profiles following single doses of heroin administered to human subjects via smoking and intravenous routes. Expand
Effective GC-MS procedure for detecting iso-LSD in urine after base-catalyzed conversion to LSD.
TLDR
A sensitive method is described to detect isolysergic acid diethylamide (iso-LSD) in urine, a byproduct of illicit preparation of LSD, which is an indication of LSD use. Expand
Passive inhalation of marijuana smoke: urinalysis and room air levels of delta-9-tetrahydrocannabinol.
TLDR
Room air levels of THC during passive smoke exposure appeared to be the most critical factor in determining whether a subject produced cannabinoid-positive urine specimens. Expand
Cathinone (Khat) and methcathinone (CAT) in urine specimens: a gas chromatographic-mass spectrometric detection procedure.
A gas chromatographic-mass spectrometric procedure for detection of cathinone (Khat) and methcathinone (CAT) in urine was developed. The compounds were detected as 4-carboethoxyhexafluorobutyrylExpand
Cyanide and thiocyanate in human saliva by gas chromatography-mass spectrometry.
TLDR
The proposed GC-MS confirmatory method was found useful when the concentrations of CN and SCN in saliva needed to be accurately determined. Expand
Effects of pyridinium chlorochromate adulterant (urine luck) on testing for drugs of abuse and a method for quantitative detection of chromium (VI) in urine.
TLDR
Chromium (VI) from PCC in a urine solution was detected by a color reaction with 1,5-diphenylcarbazide (DPC), an immediate red-violet color appeared and the ratio of absorption was used to identify the chromium compound. Expand
Forensic drug testing for opiates: I. Detection of 6-acetylmorphine in urine as an indicator of recent heroin exposure; drug and assay considerations and detection times.
TLDR
The presence of 6-AM in urine can be interpreted with confidence to mean that heroin, or 6- AM, was administered within 24 h of specimen collection and that the presence of 5-AM is not caused by morphine or codeine administration. Expand
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