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Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study
Objectives To quantify the diagnostic accuracy of selected inflammatory markers in addition to symptoms and signs for predicting pneumonia and to derive a diagnostic tool. Design Diagnostic studyExpand
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Use of Expert Panels to Define the Reference Standard in Diagnostic Research: A Systematic Review of Published Methods and Reporting
Loes C. M. Bertens and colleagues survey the published diagnostic research literature for use of expert panels to define the reference standard, characterize components and missing information, andExpand
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Diagnosing pneumonia in patients with acute cough: clinical judgment compared to chest radiography
Pneumonia is often diagnosed and treated empirically. We set out to determine the diagnostic accuracy of clinical judgment based on signs and symptoms to detect radiographic pneumonia in patientsExpand
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Development and validation of a model to predict the risk of exacerbations in chronic obstructive pulmonary disease
Purpose Prediction models for exacerbations in patients with chronic obstructive pulmonary disease (COPD) are scarce. Our aim was to develop and validate a new model to predict exacerbations inExpand
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Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care
Background Most cases of adult pertussis probably remain undiagnosed. Aim To explore the prevalence, diagnosis, and disease course of acute pertussis infection in adult patients presenting with acuteExpand
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C-reactive protein point-of-care testing and associated antibiotic prescribing.
BACKGROUND In clinical trials, the potential of point-of-care (POC) C-reactive protein (CRP) tests was demonstrated in decreasing antibiotic prescribing in adults with acute cough in generalExpand
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Amoxicillin for clinically unsuspected pneumonia in primary care: subgroup analysis
Clinically unsuspected pneumonia does benefit from antibiotic treatment in terms of duration and severity of symptoms http://ow.ly/T46up Antibiotic treatment is recommended for pneumonia [1, 2].Expand
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Undetected chronic obstructive pulmonary disease and asthma in people over 50 years with persistent cough.
BACKGROUND Chronic obstructive pulmonary disease (COPD) and asthma are underdiagnosed in primary care. AIM To determine how often COPD or asthma are present in middle-aged and older patients whoExpand
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External Validation of Prediction Models for Pneumonia in Primary Care Patients with Lower Respiratory Tract Infection: An Individual Patient Data Meta-Analysis
Background Pneumonia remains difficult to diagnose in primary care. Prediction models based on signs and symptoms (S&S) serve to minimize the diagnostic uncertainty. External validation of theseExpand
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Effectiveness of an interactive platform, and the ESC/HFA heartfailurematters.org website in patients with heart failure: design of the multicentre randomized e‐Vita heart failure trial
Electronic health support (e‐health) may improve self‐care of patients with heart failure (HF). We aim to assess whether an adjusted care pathway with replacement of routine consultations by e‐healthExpand
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