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Relationship between immunological structure and biochemical properties of human thyroid peroxidase.
TLDR
A tentative map of the surface of the hTPO molecule is proposed which associates its epitopic structure with its biochemical functions. Expand
Comparison of serum thyroid microsomal and thyroid peroxidase autoantibodies in thyroid diseases.
TLDR
Results provide strong support for the concept that TPO accounts for virtually all of the antigenic determinants reacting with the autoantibodies commonly termed anti-M antibodies. Expand
Autoimmunity as the Most Frequent Cause of Idiopathic Secondary Adrenal Insufficiency: Report of 111 Cases
TLDR
Coexistence of isolated secondary adrenal insufficiency with some autoimmune disorders in 73% of the patients under study suggests that autoimmunity is the most frequent cause of the idiopathic form of this disease. Expand
Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases
TLDR
It has been demonstrated that sera with anti‐microsomal autoantibodies from patients presenting Graves' or Hashimoto's thyroiditis diseases were able to bind to purified TPO and to inhibit in a dose‐dependent manner the mAb binding to purifiedTPO, suggesting that TPO is the thyroid antigen termed to date the microsomal antigen. Expand
Novel routine assay of thyroperoxidase autoantibodies.
TLDR
This radioimmunoassay was developed for specific and large-scale routine measurement of autoantibodies to thyroperoxidase (TPO), an enzyme recently identified as the thyroid microsomal antigen and is sensitive, easy to perform, and requires only trace amounts of purified TPO. Expand
Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis.
TLDR
Th2-mediated pendrin expression is increased in NPs of patients with CRS and might lead to increased inflammation, mucus production, and decreased mucociliary clearance, suggesting that the therapeutic benefit of dexamethasone in asthmatic patients and those with C RS might involve regulation of pendrinexpression. Expand
Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis
TLDR
The findings suggest that the changes in the expression of apoptotic molecules on the surface of T lymphocytes and thyroid follicular cells in patients with autoimmune thyroid disorders reflect their substantial involvement in the pathogenesis of GD and HT. Expand
Does TSH Trigger the Anti-thyroid Autoimmune Processes? Observation on a Large Cohort of Naive Patients with Thyroid Hemiagenesis
TLDR
Evaluated the thyroid autoimmunity incidence in patients with THA and influence of higher than average TSH level on thyroid volume (TV) and its change with age to reveal, whether TSH overstimulation may be the trigger for thyroid autoIMmunity. Expand
Anti-natrium/iodide symporter antibodies and other anti-thyroid antibodies in children with Turner's syndrome.
TLDR
Investigation of the presence of anti-NIS ab and its potential clinical significance in Turner's syndrome children found a positive correlation between the anti- NIS ab presence and the hypothyroidism and anti-nIS ab-positive sera did not suppress iodine uptake. Expand
Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer?
TLDR
The present results show that in about two-thirds of differentiated thyroid carcinomas, TPO protein is expressed, albeit to a more variable extent than normal; when present, T PO in malignant tissues is immunologically normal. Expand
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