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One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.
The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtainedExpand
Quantitative structure-activity relationships in amphotericin B derivatives.
The quantitative structure-activity relationships studies of amphotericin B and its 16 semisynthetic derivatives obtained by modification at carboxyl and amino groups have been done. The results ofExpand
The role of the carboxyl and amino groups of polyene macrolides in their interactions with sterols and their selective toxicity. A 31P-NMR study
The permeability induced by amphotericin B and vacidin A derivatives in large unilamellar lipidic vesicles containing various sterols has been studied using the proton-cation exchange method andExpand
Transfer of the polyene antibiotic amphotericin B between single-walled vesicles of dipalmitoylphosphatidylcholine and egg-yolk phosphatidylcholine
Abstract Amphotericin B transfer between single-walled vesicles of dipalmitoylphosphatidylcholine (DPPC) and of egg phosphatidylcholine, both containing 10 mol% cholesterol, has been studiedExpand
N-Methyl-N-D-fructosyl amphotericin B methyl ester (MF-AME), a novel antifungal agent of low toxicity: monomer/micelle control over selective toxicity.
Rational chemical modification of amphotericin B (AMB) led to the synthesis of sterically hindered AMB derivatives. The selected optimal compound, N-methyl-N-D-fructosyl amphotericin B methyl esterExpand
Identification of the structural elements of amphotericin B and other polyene macrolide antibiotics of the hepteane group influencing the ionic selectivity of the permeability pathways formed in the
The selectivity of the transmembrane permeability induced by polyene antibiotics was studied in human erythrocytes and related to the hemolytic potency of the drugs. The selectivity induced wasExpand
Cation permeability induced by valinomycin, gramicidin D and amphotericin B in large lipidic unilamellar vesicles studied by 31P-NMR
Permeability induced by mobile carriers and channel-forming compounds in large unilamellar lipidic vesicles (LUV) has been studied by the proteon-cation exchange method. Proton movement has beenExpand
The effect of short-term and prolonged fructose intake on VLDL-TG and relative properties on apo CIII1 and apo CII in the VLDL fraction in type IV hyperlipoproteinaemia.
Twenty two patients with hyperlipoproteinaemia type IV consumed fructose in a daily dose of 80 g for 28 days. Apart from that they kept their normal diet. We observed the considerable heterogeneityExpand
[Actual problems of dyslipidaemia treatment in Poland - 2nd Declaration of Sopot. Experts' Group Consensus endorsed by the Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy].
Actual problems of dyslipidaemia treatment in Poland — 2nd Declaration of Sopot. Experts’ Group Consensus endorsed by the Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy BeataExpand
Healthy diet for a healthy heart
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