The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Sox9 is required for cartilage formation
- W. Bi, J. Deng, Zhaoping Zhang, R. Behringer, B. Crombrugghe
- Biology, MedicineNature Genetics
- 29 April 1999
The results identify Sox9 as the first transcription factor that is essential for chondrocyte differentiation and cartilage formation and Sox9 is identified as a regulator of the chondROcyte lineage.
Interactions between Sox9 and β-catenin control chondrocyte differentiation
The results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/β-catenin signaling pathway.
NFAT and Osterix cooperatively regulate bone formation
NFAT and Osterix cooperatively control osteoblastic bone formation and may provide important insight into the management of post-transplantation osteoporosis as well as a new strategy for promoting bone regeneration in osteopenic disease.
Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene
It is shown that Cart1–homozygous mutant mice are born alive with acrania and meroanencephaly but die soon after birth — a phenotype that strikingly resembles a corresponding human syndrome caused by a neural tube closure defect.
A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice
The data suggest that a far-upstream enhancer element plays a role in regulating high levels of expression of the mouse pro alpha 2(I) collagen gene.
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.
Evidence is provided that the regulatory interaction between Sox9, Wwp2 and Med25 defines the Sox9 transcriptional mechanisms of chondrogenesis in the forming palate.
Cyclic AMP regulates Catabolite and Transient Repression in E. coli
Transient and catabolite repression of the synthesis of β-galactosidase in E. coli are related phenomena, the result of a decreased intracellular concentration of cyclic AMP. The lac operon promoter…