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Identification and Functional Expression of Four Isoforms of ATPase II, the Putative Aminophospholipid Translocase
  • J. Ding, Z. Wu, +5 authors X. Xie
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 28 July 2000
Four isoforms of ATPase II are identified in bovine brain by a combination of two major variations in their primary sequences and show that the structural variation of these isoforms has functional significance in both ATPase activity and phosholipid selectivity. Expand
Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps.
Vacuolar-type proton-translocating ATPases are complex heterooligomers that are characterized by a specific inhibition by bafilomycin A1. These enzymes have a peripheral ATP hydrolytic domain as wellExpand
Cryptic Chromosomal Abnormalities Identified in Children With Congenital Heart Disease
The results suggest that a significant percentage of children with CHD and neurologic abnormalities harbor subtle chromosomal abnormalities, and it is proposed that children who meet these two criteria should receive more extensive genetic testing to detect potential cryptic chromosome abnormalities. Expand
Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners.
The existence of high LD spanning functionally distinct TAS2R loci predicts that bitter taste responses to many compounds will be strongly correlated even when they are mediated by different genes. Expand
Identification and Reconstitution of an Isoform of the 116-kDa Subunit of the Vacuolar Proton Translocating ATPase*
We have identified a cDNA encoding an isoform of the 116-kDa subunit of the bovine vacuolar proton translocating ATPase. The predicted protein sequence of the new isoform, designated a2, consists ofExpand
Electron transfer-driven ATP synthesis in Methanococcus voltae is not dependent on a proton electrochemical gradient.
The results presented here suggest that at least one methanogenic bacterium may use a direct linkage of ATP synthesis to electron transfer, and that although cells possess an ion-translocating ATPase, methanogenesis-driven ATP synthesis does not involve the intermediacy of a transmembrane ion gradient. Expand
Characterization of the Functional Coupling of Bovine Brain Vacuolar-type H+-translocating ATPase
It is reported that Ca2+-induced uncoupling of the bovine brain V-ATPase can be reversed by imposition of a favorable membrane potential. Expand
Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate.
A population of arginine-responsive, glucose-unresponsive islets with low glucose transport rates is present at the onset of overt diabetes in BB/W rats. Expand
Isolation and reconstitution of the chloride transporter of clathrin-coated vesicles.
These studies demonstrate that the chloride transporter of vacuolar acidification systems is structurally and functionally dissociable from co-existing proton pumps and allow for investigations of pump-transporter interactions in a resolved system. Expand
Subunit G of the Vacuolar Proton Pump
Reconstitution of ATP hydrolysis was achieved by combination of recombinant subunits A, B, C, and E with either recombinant G1 or G2, demonstrating the role of these isoforms in pump function. Expand