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Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)?
TLDR
The ABC score, which uses nonlaboratory, nonweighted parameters, is a simple and accurate in identifying patients who will require MT as compared with those previously published scores.
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
TLDR
Among patients with severe trauma and major bleeding, early administration of plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1-1:2 ratio did not result in significant differences in mortality at 24 hours or at 30 days, but more patients in the 1:2:2 group achieved hemostasis and fewer experienced death due to exsanguination by 24 hours.
The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.
TLDR
Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission, and among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or Platelet ratios.
Admission Rapid Thrombelastography Can Replace Conventional Coagulation Tests in the Emergency Department: Experience With 1974 Consecutive Trauma Patients
TLDR
The r-TEG data was clinically superior to results from 5 CCTs and identified patients with an increased risk of early RBC, plasma and platelet transfusions, and fibrinolysis.
Damage control resuscitation: the new face of damage control.
TLDR
This research highlights the need to understand more fully the role of emotion in the development of learning and the importance of positive emotions in the preparation of students for exams.
Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization.
TLDR
It is demonstrated that an exsanguination protocol, delivered in an aggressive and predefined manner, significantly reduces the odds of mortality as well as overall blood product consumption.
Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients
TLDR
Sarcopenia is highly prevalent in the elderly population with traumatic injuries and represents a potential new predictor for mortality, discharge disposition, and ICU utilization, according to traditional measures of nutritional assessment.
Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival.
TLDR
Increased FFP:RBC and PLT:PRBC ratios during a period of massive transfusion improved survival after major trauma and should be designed to achieve these ratios to provide maximal benefit.
Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission.
TLDR
Graphical r-TEG results are available within minutes, correlate with conventional coagulation test that are not as rapidly available, and are predictive of early transfusions of packed red blood cells, plasma, and platelets.
Defining when to initiate massive transfusion: A validation study of individual massive transfusion triggers in PROMMTT patients
BACKGROUND Early predictors of massive transfusion (MT) would prevent undertriage of patients likely to require MT. This study validates triggers using the Prospective Observational Multicenter Major
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