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Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism
Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on κ-opioid agonists in the mouse writhing assay
- J. Broadbear, S. Stevens Negus, E. Butelman, B. Costa, J. Woods
- Biology, MedicinePsychopharmacology
- 1 July 1994
SC administered nor-BNI selectively antagonized agonist activity mediated through kappaopioid receptors without differentiating between kappa subtypes, suggesting that their antinociceptive effects were mediated at least in part by nor-bnI-sensitive kappa receptors.
Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain
GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine
Functional assessment and partial characterization of [3H](+)-pentazocine binding sites on cells of the immune system
Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity
Phenylpiperidine opioid antagonists that promote weight loss in rats have high affinity for the κ2B (enkephalin-sensitive) binding site
Differentiation of σ ligand‐activated receptor subtypes that modulate NMDA‐evoked [3H]‐noradrenaline release in rat hippocampal slices
In vitro functional evidence is provided for a σ receptor type preferentially sensitive to BD‐737, reduced haloperidol, BD‐1008 and also to NE‐100, that differs from the already identified σ1, σ2 and σ3 sites.
Pharmacological activities of optically pure enantiomers of the κ opioid agonist, U50,488, and its cis diastereomer: evidence for three κ receptor subtypes