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The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism
The transcriptional profile generated by a crude marine natural product recapitulated the mechanistic prediction from the pure active component of Mycobacterium tuberculosis and provide a rational basis for the selection of critical metabolic targets for screening for new agents with improved activity against this important human pathogen.
Marine natural products.
This review covers the literature published in 2004 for marine natural products, with 693 citations referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms.
Biomedical Potential of Marine Natural Products
Marine natural products, the secondary or nonprimary metabolites produced by organisms that live in the sea, have received increasing attention from chemists and pharmacologists during the last two
E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp.
Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic
Natural product growth inhibitors of Mycobacterium tuberculosis.
This review covers natural products (secondary metabolites) with reported growth inhibitory activity towards Mycobacterium tuberculosis or related organisms with the express intent of identifying novel scaffolds for the development of new antituberculosis agents.
Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis.
Two new tricyclic thiazine-containing quinolinequinone alkaloids were isolated from the New Zealand ascidian Aplidium species and inhibited the in vitro production of superoxide by PMA-stimulated human neutrophils in a dose-dependent manner.
Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya
We present the isolation and characterization of seven novel (natural) pyrroloiminoquinones, the makaluvamines A-F (1-6), makaluvone (7), and the known compounds discorhabdin A (8) and damirone B (9)
Antimycobacterial natural products.
  • B. Copp
  • Chemistry, Medicine
    Natural product reports
  • 25 November 2003
This review covers the literature published between January 1990 and December 2002 (inclusive) for natural products with reported antimycobacterial activity, with 248 citations to 352 compounds
New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.
Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed.
Isodiplamine, cystodytin K and lissoclinidine: novel bioactive alkaloids from the New Zealand ascidian Lissoclinum notti
Abstract A study of the bioactive crude extract of the New Zealand ascidian Lissoclinum notti led to the isolation of the new pyridoacridine alkaloids isodiplamine ( 4 ), cystodytin K ( 5 ) and