The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism
- H. Boshoff, T. Myers, B. Copp, M. McNeil, Michael A Wilson, C. Barry
- BiologyJournal of Biological Chemistry
- 17 September 2004
The transcriptional profile generated by a crude marine natural product recapitulated the mechanistic prediction from the pure active component of Mycobacterium tuberculosis and provide a rational basis for the selection of critical metabolic targets for screening for new agents with improved activity against this important human pathogen.
Marine natural products.
- J. Blunt, B. Copp, M. Munro, P. Northcote, M. Prinsep
- Environmental Science, ChemistryNatural product reports (Print)
- 2006
This review covers the literature published in 2004 for marine natural products, with 693 citations referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms.
Biomedical Potential of Marine Natural Products
- C. Ireland, B. Copp, M. Foster, L. McDonald, D. Radisky, J. C. Swersey
- Biology, Chemistry
- 1993
The intent of this chapter is to look back at the evolution of biomedically oriented natural product studies of marine organisms, to chronicle the key developments, discoveries, and advances in the level of sophistication that have fueled further interest in this field, and to look forward at the future biomedical potential of marine natural products.
Rossinones A and B, biologically active meroterpenoids from the Antarctic ascidian, Aplidium species.
- D. Appleton, Cheah Shiau Chuen, M. Berridge, V. Webb, B. Copp
- Chemistry, BiologyJournal of Organic Chemistry
- 29 October 2009
Rossinones A and B, biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic methods and exhibit anti-inflammatory, antiviral and antiproliferative activities.
Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya
- D. Radisky, E. Radisky, L. Barrows, B. Copp, R. Kramer, C. Ireland
- Biology
- 1 March 1993
The structure determination of the new compounds are reported and preliminary evidence for the ability of this class of metabolites to inhibit the function of mammalian topoisomerase 119 and to inhibits the growth of human ovarian tumor in an athymic mouse model is reported.
Antimycobacterial natural products.
- B. Copp
- ChemistryNatural product reports (Print)
- 25 November 2003
This review covers the literature published between January 1990 and December 2002 (inclusive) for natural products with reported antimycobacterial activity, with 248 citations to 352 compounds…
E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp.
Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic…
New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.
- A. Longeon, B. Copp, M. Bourguet-Kondracki
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 15 August 2010
Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.
Pyrroloiminoquinone alkaloid alkaloids are a novel class of HIF-1α inhibitors, which interrupt the protein-protein interaction between Hif-1 α and p300 and consequently reduce H IF-related transcription.
Marine natural products.
- J. Blunt, B. Copp, R. Keyzers, M. Munro, M. Prinsep
- Environmental Science, ChemistryNatural product reports (Print)
- 2014
This review covers the literature published in 2012 for marine natural products, with 1035 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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