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The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism
- H. Boshoff, T. Myers, B. Copp, M. McNeil, M. Wilson, C. Barry
- Medicine, Biology
- Journal of Biological Chemistry
- 17 September 2004
The differential transcriptional response of Mycobacterium tuberculosis to drugs and growth-inhibitory conditions was monitored to generate a data set of 430 microarray profiles. Unbiased grouping of… Expand
Marine natural products.
This review covers the literature published in 2004 for marine natural products, with 693 citations (491 for the period January to December 2004) referring to compounds isolated from marine… Expand
Biomedical Potential of Marine Natural Products
Marine natural products, the secondary or nonprimary metabolites produced by organisms that live in the sea, have received increasing attention from chemists and pharmacologists during the last two… Expand
Rossinones A and B, biologically active meroterpenoids from the Antarctic ascidian, Aplidium species.
- D. R. Appleton, Cheah Shiau Chuen, M. Berridge, V. L. Webb, B. Copp
- Chemistry, Medicine
- The Journal of organic chemistry
- 29 October 2009
Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic… Expand
E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp.
Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic… Expand
Natural product growth inhibitors of Mycobacterium tuberculosis.
This review covers natural products (secondary metabolites) with reported growth inhibitory activity towards Mycobacterium tuberculosis or related organisms. Such compounds have been isolated from a… Expand
Antimycobacterial natural products.
- B. Copp
- Medicine, Chemistry
- Natural product reports
- 25 November 2003
This review covers the literature published between January 1990 and December 2002 (inclusive) for natural products with reported antimycobacterial activity, with 248 citations to 352 compounds… Expand
Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya
We present the isolation and characterization of seven novel (natural) pyrroloiminoquinones, the makaluvamines A-F (1-6), makaluvone (7), and the known compounds discorhabdin A (8) and damirone B (9)… Expand
Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis.
Ascidiathiazones A (3) and B (4), two new tricyclic thiazine-containing quinolinequinone alkaloids, were isolated from the New Zealand ascidian Aplidium species. Both compounds inhibited the in vitro… Expand
Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
- A. Longeon, B. Copp, +6 authors Marie-Lise Bourguet-Kondracki
- Biology, Medicine
- Marine drugs
- 24 May 2011
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass… Expand