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Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial.
STUDY OBJECTIVE To determine the efficacy of a corticosteroid in reducing the short-term mortality of patients with severe alcoholic hepatitis. DESIGN Randomized, double-blind, placebo-controlledExpand
Ursodeoxycholic acid in primary biliary cirrhosis.
  • B. Combes
  • Medicine
  • Seminars in liver disease
  • 1 May 1997
In patients with primary biliary cirrhosis (PBC), ursodeoxycholic acid (ursodiol) improves laboratory test markers of cholestasis and hepatic inflammation as well as some hepatic histologicalExpand
Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay
Primary biliary cirrhosis (PBC) is sometimes diagnosed based on a positive antimitochondrial antibody in the appropriate clinical setting without a liver biopsy. Although a liver biopsy can assessExpand
Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease.
BACKGROUND Spironolactone, an aldosterone antagonist, has been demonstrated to decrease mortality in human patients when added to other cardiac therapies. HYPOTHESIS Spironolactone in addition toExpand
Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane.
Abstract A patient with persistent Australia (Au) antigenaemia after post-transfusion hepatitis developed membranous glomerulonephritis. Immunofluorescent staining of kidney tissue revealedExpand
Cerebral edema: a major complication of massive hepatic necrosis.
A review was conducted of 32 patients dying of massive hepatic necrosis and subject to complete autopsy examination. Sixteen of the 32 patients were found to have cerebral edema and 4 of these hadExpand
Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis
OBJECTIVES:Generalized pruritus is a common complication of cholestatic liver diseases, although its pathogenesis remains elusive. Current treatments are often inadequate and may be poorly tolerated,Expand
The negative effect of repeated equine chorionic gonadotropin treatment on subsequent fertility in Alpine goats is due to a humoral immune response involving the major histocompatibility complex.
In dairy goats, the use of eCG as a convenient hormone for the induction of ovulation is necessary for out-of-season breeding and artificial insemination. However, repeated eCG treatments areExpand
A direct assessment of the importance of conjugation for biliary transport of sulfobromophthalein sodium.
Abstract The importance of conjugation for maximal excretion of sulfobromophthalein sodium (BSP) into bile has been examined directly by comparison of the biliary excretion of dye when either free orExpand
The biliary excretion of sulfobromophthalein sodium (BSP) in the rat as a conjugate of glycine and glutamic acid.
  • B. Combes
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1 August 1959
Sulfobromophthalein sodium (BSP) is a phthalein dye that is removed from blood predominantly by the liver and excreted into the bile (2). Removal is impaired in the presence of hepatocellular damage,Expand
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