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Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum.
All eight enzymes required for de novo heme biosynthesis have been predicted from the nuclear genome of the human malaria parasite Plasmodium falciparum. We have studied the subcellular localizationExpand
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A Subtilisin-like Protein in Secretory Organelles of Plasmodium falciparum Merozoites*
In the vertebrate host, the malaria parasite invades and replicates asexually within circulating erythrocytes. Parasite proteolytic enzymes play an essential but poorly understood role in erythrocyteExpand
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Plasmodium falciparum: the importance of IgM in the rosetting of parasite-infected erythrocytes.
Abstract Clough, B., Atilola, F. A., Black, J., and Pasvol, G. 1998. Plasmodium falciparum : The importance of IgM in the rosetting of parasite-infected erythrocytes. Experimental Parasitology 89,Expand
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K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells
Toxoplasma gondii is the most common protozoan parasitic infection in man. Gamma interferon (IFNγ) activates haematopoietic and non-haematopoietic cells to kill the parasite and mediate hostExpand
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Nifs and Sufs in malaria
This review assembles data from three bodies of literature (bacterial genetics, plastid biogenesis and parasitology) that seldom have much direct cross‐talk. After overcoming terminologicalExpand
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Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
Malaria is an infectious disease caused by parasites of the genus Plasmodium, which leads to approximately one million deaths per annum worldwide. Chemical validation of new antimalarial targets isExpand
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Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum.
Elongation factor Tu (EF-Tu) is encoded by the tuf gene of the plastid organelle of the malaria parasite Plasmodium falciparum. A range of structurally unrelated inhibitors of this GTP-dependentExpand
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Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)
Graphical abstract
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Cell Death of Gamma Interferon-Stimulated Human Fibroblasts upon Toxoplasma gondii Infection Induces Early Parasite Egress and Limits Parasite Replication
ABSTRACT The intracellular protozoan parasite Toxoplasma gondii is a major food-borne illness and opportunistic infection for the immunosuppressed. Resistance to Toxoplasma is dependent on gammaExpand
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TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles
Interferon gamma (IFNγ) is the major proinflammatory cytokine conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii by inducing the destruction of the parasitophorous vacuoleExpand
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