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Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.
Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquidExpand
Data support DA as a prolactin inhibitory factor (PIF) in the anterior pituitary of several species using H-labelled DA, dihydroergocryptine (DHE), DHE and spiroperidol. Expand
The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.
In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin and three highly malignant cell types from three different species, including man, die. Expand
Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: determination of affinities and specificities of monoclonal antibodies by using biotin-labeled antibodies
The heterogeneity of radiolabeled CEA as indicated by the low fraction bound by one of the monoclonal antibodies is shown to be most probably an artifact resulting from radioiodination damage. Expand
Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes.
Histological examination of sections of animal brains revealed that treatment with I-As protein plus myelin basic protein 91-103 peptide prevents the development of inflammatory lesions characteristic of experimental allergic encephalomyelitis, suggesting treatment with MHC-self-peptide complexes could serve as a highly specific therapeutic modality in treating autoimmune disease. Expand
Pterin-6-aldehyde, a cancer cell catabolite: identification and application in diagnosis and treatment of human cancer.
Active folic acid degradation with the formation pterin-6-aldehyde is a previously undescribed characteristic of cancer cells in tissue culture and is not found in the urine of healthy patients at this level of detection unless their diets are supplemented with folic Acid. Expand
N5-methyltetrahydrofolate: homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells.
Malignant cells (J111, L1210, W-256) and human embryonic cells (FL) are unable to survive and grow when homocystine replaces methionine in tissue culture media containing excess vitamin B12 and folic acid, and extracts of these same cells when grown in media containing methamphetamine have diminished N5-methyltetrahydrofolate. Expand
Energy transfer between two peptides bound to one MHC class II molecule.
The energy-transfer data suggest that the two binding sites of floppy alpha beta arise from splitting apart a putative large, single binding site region in compact alpha beta. Expand
A fluorimetric method for quantitation in the picomole range of N1-methylnicotinamide and nicotinamide in serum.
Abstract A method is described for the fluorimetric determination of N 1 -methylnicotinamide in deproteinized serum extract and of nicotinamide after extraction into ethyl acetate from deproteinizedExpand
Stimulation of T cells by antigenic peptide complexed with isolated chains of major histocompatibility complex class II molecules.
The binding of an acetylated N-terminal peptide of myelin basic protein to purified individual alpha and beta chains of murine I-Ak molecules shows that in vitro cloned T cells are triggered by complexes of specific antigenic peptides and isolated individual chains of their cognate MHC proteins. Expand