B. Clark

Publications9
h-index8
Citations659
Highly Influential Citations18
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Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.
Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid…
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Amino acid sequences of three bombesin-like peptides from canine intestine extracts.
TLDR
Radioimmunoassay of brain extracts after sequential purification revealed the presence of similar large and small forms of immunoreactive bombesin peptides, but with apparent tissue concentrations of about 4% of those present in intestinal muscle.
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The in vitro inhibition of the N-demethylation of pethidine by phenelzine (Phenethylhydrazine).
  • B. Clark
  • Biology, Chemistry
    Biochemical pharmacology
  • 1 December 1967
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Analysis of the inhibition of pethidine N‐demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man
TLDR
It is concluded that since many different groups of drugs, including monoamineoxidase inhibitors, tranquillizers, tricyclic antidepressants, steroids, nalorphine, SKF 525A and barbiturates compete for cytochrome P450 reductase, it is possible that this mechanism may account for the observed interactions of these various drugs in man.
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Synthesis of γ‐Glutamyldopamine and Other Peptidoamines in the Nervous System of Aplysia californica
TLDR
The synthesis of a series of γ‐glutamyl amines (γ‐Glu‐amines) by nervous tissue of the marine mollusc Aplysia californica is described and identification was made by comparing the chromatographic properties (HPLC, TLC, and LC) of the isolated conjugates with chemically synthesizedγ‐GLU‐amines before and after acid hydrolysis.
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Canine bombesin‐like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog.
TLDR
Gastrin releasing peptide 10 was cleared from the circulation three times faster than the larger forms and this may account for the apparent differences in potency, and the larger canine and porcine peptides were more potent than the decapeptide.
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Potency of natural and synthetic canine gastrin-releasing decapeptide on canine antral muscle.
TLDR
The full biological potency on canine antral motility and the presence of GRP-10 in nerve fibers in the gut and in the spinal cord suggest a possible role for this peptide as a neurotransmitter or neuromodulator in regulation of smooth muscle contraction.
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Chemical synthesis of urotensin II, a somatostatin like peptide in the caudal neurosecretory system of fishes.
TLDR
The pure, synthetic UII, obtained in 7.6% yield from oxidized crude U II, was indistinguishable from pure, native UII in specific bioactivity, amino acid sequence, and retention time in each of two different HPLC systems.
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Role of glutamine synthetase in phenazine antibiotic production by Pantoea agglomerans Eh1087.
TLDR
It is concluded that the 2 nitrogens in the Phenazine nucleus originate from glutamine and the intracellular glutamine synthesized by Eh1087 is a source of the phenazine nucleus nitrogens even in glutamine-rich environments.
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