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Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11
- Y. Hwang, B. Chung, D. Ortmann, Nobuaki Hattori, Hannes-Christian Moeller, A. Khademhosseini
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 6 October 2009
Recently, various approaches for controlling the embryonic stem (ES) cell microenvironment have been developed for regulating cellular fate decisions. It has been reported that the lineage specific… Expand
Human neural stem cell growth and differentiation in a gradient-generating microfluidic device.
This paper describes a gradient-generating microfluidic platform for optimizing proliferation and differentiation of neural stem cells (NSCs) in culture. Microfluidic technology has great potential… Expand
Nano/Microfluidics for diagnosis of infectious diseases in developing countries.
- W. G. Lee, Yun-Gon Kim, B. Chung, U. Demirci, A. Khademhosseini
- Advanced drug delivery reviews
- 18 March 2010
Nano/Microfluidic technologies are emerging as powerful enabling tools for diagnosis and monitoring of infectious diseases in both developed and developing countries. Miniaturized nano/microfluidic… Expand
Stop-flow lithography to generate cell-laden microgel particles.
Encapsulating cells within hydrogels is important for generating three-dimensional (3D) tissue constructs for drug delivery and tissue engineering. This paper describes, for the first time, the… Expand
Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering.
Microfluidic technologies are emerging as an enabling tool for various applications in tissue engineering and cell biology. One emerging use of microfluidic systems is the generation of… Expand
A microwell array system for stem cell culture.
- Hannes-Christian Moeller, M. Mian, Shamit Shrivastava, B. Chung, A. Khademhosseini
- Materials Science, Medicine
- 1 February 2008
Directed embryonic stem (ES) cell differentiation is a potentially powerful approach for generating a renewable source of cells for regenerative medicine. Typical in vitro ES cell differentiation… Expand
Controlled-size embryoid body formation in concave microwell arrays.
- Y. Choi, B. Chung, D. Lee, A. Khademhosseini, Jong-Hoon Kim, S. Lee
- Biology, Medicine
- 1 May 2010
Embryonic stem (ES) cells hold great potential as a renewable cell source for regenerative medicine and cell-based therapy. Despite the potential of ES cells, conventional stem cell culture methods… Expand
Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber
- W. Saadi, S. Rhee, F. Lin, Behrad Vahidi, B. Chung, N. L. Jeon
- Chemistry, Medicine
- Biomedical microdevices
- 25 May 2007
We have developed a simple microfluidic device for generating stable concentration gradients in 2D and 3D environments. The device, termed the Ladder Chamber, uses a two-compartment diffusion system… Expand
Microfluidics for drug discovery and development: from target selection to product lifecycle management.
Microfluidic technologies' ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristics… Expand
Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model.
We have developed a size-controllable spheroidal hepatosphere and heterosphere model by mono-culturing of primary hepatocytes and by co-culturing primary hepatocytes and hepatic stellate cells… Expand