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Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11
Recently, various approaches for controlling the embryonic stem (ES) cell microenvironment have been developed for regulating cellular fate decisions. It has been reported that the lineage specificExpand
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Human neural stem cell growth and differentiation in a gradient-generating microfluidic device.
This paper describes a gradient-generating microfluidic platform for optimizing proliferation and differentiation of neural stem cells (NSCs) in culture. Microfluidic technology has great potentialExpand
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Nano/Microfluidics for diagnosis of infectious diseases in developing countries.
Nano/Microfluidic technologies are emerging as powerful enabling tools for diagnosis and monitoring of infectious diseases in both developed and developing countries. Miniaturized nano/microfluidicExpand
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Stop-flow lithography to generate cell-laden microgel particles.
Encapsulating cells within hydrogels is important for generating three-dimensional (3D) tissue constructs for drug delivery and tissue engineering. This paper describes, for the first time, theExpand
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Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering.
Microfluidic technologies are emerging as an enabling tool for various applications in tissue engineering and cell biology. One emerging use of microfluidic systems is the generation ofExpand
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A microwell array system for stem cell culture.
Directed embryonic stem (ES) cell differentiation is a potentially powerful approach for generating a renewable source of cells for regenerative medicine. Typical in vitro ES cell differentiationExpand
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Controlled-size embryoid body formation in concave microwell arrays.
Embryonic stem (ES) cells hold great potential as a renewable cell source for regenerative medicine and cell-based therapy. Despite the potential of ES cells, conventional stem cell culture methodsExpand
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Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber
We have developed a simple microfluidic device for generating stable concentration gradients in 2D and 3D environments. The device, termed the Ladder Chamber, uses a two-compartment diffusion systemExpand
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Microfluidics for drug discovery and development: from target selection to product lifecycle management.
Microfluidic technologies' ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristicsExpand
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Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model.
We have developed a size-controllable spheroidal hepatosphere and heterosphere model by mono-culturing of primary hepatocytes and by co-culturing primary hepatocytes and hepatic stellate cellsExpand
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