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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.
Abeta1-42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role in Alzheimer's pathogenesis. Neurotoxicity of amyloid beta protein (Abeta) has been attributed to itsExpand
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  • Open Access
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.
The dementia in Alzheimer disease (AD) is usually attributed to widespread neuronal loss in conjunction with the pathologic hallmarks of intracellular neurofibrillary tangles and extracellularExpand
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Self-assembly of Abeta(1-42) into globular neurotoxins.
Amyloid beta 1-42 (Abeta(1-42)) is a self-associating peptide that becomes neurotoxic upon aggregation. Toxicity originally was attributed to the presence of large, readily formed Abeta fibrils, butExpand
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Vaccination with soluble Aβ oligomers generates toxicity‐neutralizing antibodies
In recent studies of transgenic models of Alzheimer's disease (AD), it has been reported that antibodies to aged beta amyloid peptide 1–42 (Aβ1−42) solutions (mixtures of Aβ monomers, oligomers andExpand
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Self-assembly of Aβ1-42 into globular neurotoxins
Amyloid β 1−42 (Aβ1-42) is a self-associating peptide that becomes neurotoxic upon aggregation. Toxicity originally was attributed to the presence of large, readily formed Aβ fibrils, but a varietyExpand
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Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release.
A common feature of many neurodegenerative disorders is an abundance of activated glial cells (astrocytes and microglia). In Alzheimer's disease (AD), activated astrocytes are in close apposition toExpand
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Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release
A common feature of many neurodegenerative disorders is an abundance of activated glial cells (astrocytes and microglia). In Alzheimer's disease (AD), activated astrocytes are in close apposition toExpand
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Selective neuronal degeneration induced by soluble oligomeric amyloid beta‐protein
The prevailing amyloid hypothesis for Alzheimer's disease (AD) holds that amyloid β‐protein (Aβ) causes neuronal degeneration by forming neurotoxic fibrillar structures. Yet, many aspects of ADExpand
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Insertion of membrane proteins into discoidal membranes using a cell-free protein expression approach.
We report a cell-free approach for expressing and inserting integral membrane proteins into water-soluble particles composed of discoidal apolipoprotein-lipid bilayers. Proteins are inserted into theExpand
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  • Open Access
HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells
  • N. Duru, M. Fan, +12 authors J. Li
  • Biology, Medicine
  • Clinical Cancer Research
  • 22 October 2012
Purpose: To understand the role of HER2-associated signaling network in breast cancer stem cells (BCSC) using radioresistant breast cancer cells and clinical recurrent breast cancers to evaluateExpand
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  • Open Access