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Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia.
TLDR
Results show that PD-1 expression among B-NHLs is mainly associated with SLL/CLL and is influenced by activation of the CD40/CD40L pathway, and represents a useful tool to differentiate SLL-CLL from other small B-cell lymphomas.
A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients
TLDR
The present study shows that open-lung biopsy provided a contributive result in 78% of ARDS patients with a negative bronchoalveolar lavage, and survival of AR DS patients improved when open- lung biopsies was contributive.
Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.
TLDR
An antitumoral role for B cells in the cHL microenvironment and a stronger stromal influence of the PD1 pathway in H/TCRBCL than cHL are suggested.
Does the extent of lymph node dissection influence outcome in patients with stage I non-small-cell lung cancer?
TLDR
Importance of lymph node dissection affects patients outcome, while it does not enhance the operative mortality, and two mediastinal stations sampled are suggested as possible pragmatic markers of the quality of lymphadenectomy.
PD-1 is a novel regulator of human B-cell activation.
TLDR
It is determined that during TLR9 activation, blockade of PD-1/PD-Ls pathways indeed increased B-cell activation, proliferation and the production of inflammatory cytokines, and highlight the importance of devising future therapies able to modulate lymphocyte activation through the targeting of the PD- 1/ PD- Ls pathways.
Primary Intrathoracic Synovial Sarcoma: A Clinicopathologic Study of 40 t(X;18)-Positive Cases From the French Sarcoma Group and the Mesopath Group
TLDR
In conclusion, intrathoracic SS are rare but aggressive tumors with poor prognosis in this unusual location and the detection of SYT-SSX fusion transcripts is a valuable diagnostic adjunct.
High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia.
TLDR
The results suggest that down-regulation of the BTLA-HVEM pathway may be involved in germinal center B-cell activation and the specific high expression of BTLA in B-CLL/SLL represents a new potential diagnostic tool.
Large cell neuroendocrine carcinoma of the lung: an aggressive disease potentially treatable with surgery.
TLDR
Although overall survival after resection was substantial, large cell neuroendocrine carcinoma frequently showed pathologic features of occult metastatic disease, such as lymph node or vessel invasion, or both.
LAT regulates gammadelta T cell homeostasis and differentiation.
TLDR
Mice homozygous for a mutation of the three C-terminal LAT tyrosine residues showed a block in alphabeta Tcell development and a partially impaired gammadelta T cell development, indicating an essential regulator of T cell homeostasis and terminal differentiation.
Neural cell adhesion molecule expression in renal cell carcinomas: relation to metastatic behavior.
TLDR
A retrospective immunohistochemical analysis of NCAM expression in primary renal tumors found that patients with NCAM-expressing RCCs had a lower survival rate and a higher risk of adrenal and CNS metastases, especially in the first 2 years after surgery.
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