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Analysis of the circular RNA transcriptome in endometrial cancer
TLDR
The circular transcriptome specific for EC as determined by RNA sequencing found that the overall abundance of circRNAs is lower in EC than in normal endometrium and there are numerous ‘hotspot’ genes from whichcircRNAs are transcribed that may account for alterations in circRNA expression between the normal and malignantendometrium. Expand
Characterization of circular RNAs landscape in multiple system atrophy brain
TLDR
Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP1, were identified and validated as specifically over‐expressed in MSA frontal cortex and revealed their over‐expression in the white matter of the MSA cortical tissue. Expand
The emerging role of long non-coding RNAs in endometrial cancer.
TLDR
This review summarizes recent advances in the understanding of lncRNAs in cancer biology and highlights the potential for lncRNA as diagnostic biomarkers and therapeutics, and focuses on the poorly understood role of l NC RNAs in endometrial cancer. Expand
Unique Transcriptome Patterns of the White and Grey Matter Corroborate Structural and Functional Heterogeneity in the Human Frontal Lobe
TLDR
This study provides the first reference data set for a normal human frontal lobe, which will be useful in comparative transcriptome studies of cerebral disorders, in particular, neurodegenerative diseases. Expand
Changes in circular RNA expression patterns during human foetal brain development.
TLDR
This study showed that circular and linear RNAs have independent expression patterns, and that circular transcriptomes from different developing stages have distinct characteristics in terms of transcript abundance and isoform diversity. Expand
Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer.
TLDR
Four lincRNAs, characterised in this study, represent high priority genes to be tested for functional significance in the pathogenesis and/or progression of endometrial cancer and have potential to be released into the bloodstream. Expand
High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation
TLDR
This study has demonstrated for the first time that a primate-specific lincRNA regulates the expression of genes critical to human oligodendrocyte maturation, which in turn might be regulated by an antisense counterpart. Expand
Coding and non-coding transcriptome of mesial temporal lobe epilepsy: Critical role of small non-coding RNAs
TLDR
Using RNA- and small RNA-sequencing in parrallel, differentially expressed genes in the hippocampus and cortex of MTLE patients who had undergone surgical resection and non-epileptic controls are identified and specific miRNAs may be key regulators of multiple pathways related to MTLE pathology. Expand
RNA sequencing reveals pronounced changes in the noncoding transcriptome of aging synaptosomes
TLDR
This study uncovers a new layer of transcriptional regulation which is targeted by aging within the local environment of interconnecting neuronal cells within aging mice. Expand
Region-specific expression of circular RNAs in the mouse brain
TLDR
This study showed that circular and linear RNAs have independent expression patterns despite being derived from the same genomic locus, and that circular transcriptomes from different brain region have distinct characteristics in terms of transcript abundance and composition. Expand
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