• Publications
  • Influence
Tumor cells can escape DNA‐damaging cisplatin through DNA endoreduplication and reversible polyploidy
Cancer chemotherapy can induce tumor regression followed, in many cases, by relapse in the long‐term. Thus this study was performed to assess the determinants of such phenomenon using an in vivoExpand
  • 175
  • 14
Heavy-Chain Deposition Disease
Light-chain amyloidosis and light-chain deposition disease are closely related processes characterized by tissue deposition of organized (fibrillar) or nonorganized material related to monoclonalExpand
  • 106
  • 3
Inconstant association between 27-kDa heat-shock protein (Hsp27) content and doxorubicin resistance in human colon cancer cells. The doxorubicin-protecting effect of Hsp27.
To investigate the role of the small 27-kDa heat-shock protein (Hsp27) in the intrinsic resistance of colon cancer cells to doxorubicin, we modified Hsp27 expression either genetically byExpand
  • 95
  • 1
The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models
In spite of the novel strategies to treat colon cancer, mortality rates associated with this disease remain consistently high. Tumour recurrence has been linked to the induction of resistance towardsExpand
  • 43
  • 1
New Ursolic and Betulinic Derivatives as Potential Cytotoxic Agents
Fifteen new ursolic and betulinic triterpenoids, bearing various functionalities at C-3 and C-28 were synthesized as potential cytotoxic agents. All compounds were obtained by a hemisynthetic routeExpand
  • 20
  • 1
Deleterious effect of serum proteins on the amphotericin B-induced potentiation of cisplatin in human colon cancer cells.
Inherent resistance of colon cancer cells to cis-diamminedichloroplatinum(II) (CDDP) is partly attributed to reduced drug penetration through plasma membrane. Amphotericin B (AmB), a polyeneExpand
  • 12
  • 1
Nucleoside-lipid-based nanoparticles for cisplatin delivery.
The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybridExpand
  • 54
  • 21
Saponins-mediated potentiation of cisplatin accumulation and cytotoxicity in human colon cancer cells.
The triterpene saponins jenisseensosides A, B, C, D were found to increase the accumulation and cytotoxicity of the anticancer agent cisplatin in human colon tumor cells. These compounds areExpand
  • 27
Bidentatoside I, a new triterpene saponin from Achyranthes bidentata.
Bidentatoside I (1) is a new triterpene saponin bearing an unusual dioxopropionic acid unit, isolated from the roots of Achyranthes bidentata. Structural elucidation was performed mainly by chemicalExpand
  • 18