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Identification of Cellular Factors Associated with the 3′-Nontranslated Region of the Hepatitis C Virus Genome*
Chronic infection by hepatitis C virus (HCV) is the leading cause of severe hepatitis that often develops into liver cirrhosis and hepatocellular carcinoma. The molecular mechanisms underlying HCVExpand
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Depolarization of mitochondrial membrane potential is the initial event in non-nucleoside reverse transcriptase inhibitor efavirenz induced cytotoxicity
Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and an active constituent of the highly active antiretroviral therapy regime. It has significantly contributed in control andExpand
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Genetic and morphological stability of six-year-old transgenic Tylophora indica plants
Transgenic plants of Tylophora indica obtained via somatic embryogenesis through genetic transformation by Agrobacterium rhizogenes have been maintained in vitro for over 6 years and the comparisonExpand
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Novel thioglycosyl analogs of glycosyltransferase substrates as antiviral compounds against classical swine fever virus and hepatitis C virus.
Hepatitis C virus (HCV) and classical swine fever virus (CSFV) are important pathogens for which new therapeutic approaches are in high demand. Herein, we report the synthesis of newly designedExpand
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Combinations of siRNAs against La Autoantigen with NS5B or hVAP-A Have Additive Effect on Inhibition of HCV Replication
Hepatitis C virus is major cause of chronic liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Presently available direct-acting antiviral drugs have improvedExpand
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Anti‐HCV Activity from Semi‐purified Methanolic Root Extracts of Valeriana wallichii
Hepatitis C virus (HCV) is a serious global health problem affecting approximately 130–150 million individuals. Presently available direct‐acting anti‐HCV drugs have higher barriers to resistance andExpand
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The Fate of Integrated Ri T-DNA rol Genes during Regeneration via Somatic Embryogenesis in Tylophora indica
The fate of integrated Ri T-DNA rol genes during regeneration via indirect somatic embryogenesis and stability of its effect on morphology and tylophorine content of Ri-transformed plants have beenExpand
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Determination of swertiamarin and amarogentin content and evaluation of antibacterial activity in Eastern Himalayan species of Swertia L.
Introduction: The genus Swertia is known to contain many bioactive compounds having pharmacological activities. Biochemical fingerprinting can be useful in screening elite populations within andExpand
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Endoplasmic reticulum stress leads to mitochondria-mediated apoptosis in cells treated with anti-HIV protease inhibitor ritonavir
Background and AimsEndoplasmic reticulum (ER) stress is a growing concern for drug-induced toxicity which causes several side effects. Ritonavir, a potent HIV protease inhibitor, induces both ER andExpand
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Mitochondrial dysfunctions in HIV infection and antiviral drug treatment
ABSTRACT Introduction: With the introduction of highly active anti-retroviral therapy (HAART), treatment of HIV infection has improved radically, shifting the concept of HIV disease from a highlyExpand