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INBREEDING DEPRESSION AND ITS EVOLUTIONARY CONSEQUENCES
The evidence that the evolution of breeding systems of animals and plants has been significantly influenced by the occurrence of inbreeding depression is reviewed, and the contemporary genetic theory of inmarriage depression and heterosis and the experimental data concerning the strength of in breeding depression are considered. Expand
Rates of spontaneous mutation.
It is now possible to specify some of the evolutionary forces that shape these diverse mutation rates in broad groups of organisms. Expand
The effect of deleterious mutations on neutral molecular variation.
Observed reductions in molecular variation in low recombination genomic regions of sufficiently large size, for instance in the centromere-proximal regions of Drosophila autosomes or in highly selfing plant populations, may be partly due to background selection against deleterious mutations. Expand
A Model for the Evolution of Dioecy and Gynodioecy
The equilibria generated by the model agree closely with the results of genetical studies of those dioecious species with male-determining Y chromosomes that have been investigated, in which both male-and female-sterility factors have been found, showing complementary dominance relations and no crossing-over between the loci. Expand
Effective population size and patterns of molecular evolution and variation
- B. Charlesworth
- Biology, Medicine
- Nature Reviews Genetics
- 1 March 2009
The properties of Ne are reviewed in a variety of different situations of biological interest, and advances in genomic techniques are giving new insights into how selection shapes Ne. Expand
The Relative Rates of Evolution of Sex Chromosomes and Autosomes
The frequently disproportionate effects of the sex chromosomes on interspecific inviability or sterility are consistent with the hypothesis that the gene differences concerned involve recessive or partially recessive alleles fixed by selection. Expand
The evolutionary dynamics of repetitive DNA in eukaryotes
Features of the organization of repetitive sequences in eukaryotic genomes, and their distribution in natural populations, reflect the evolutionary forces acting on selfish DNA. Expand
Steps in the evolution of heteromorphic sex chromosomes
Evidence that recombination suppression occurs progressively in evolutionarily independent cases is reviewed, suggesting that selection drives loss of recombination over increasingly large regions. Expand
The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations.
Levels of neutral genetic diversity in populations subdivided into two demes were studied by multilocus stochastic simulations, showing that, with population subdivision, local selection enhances between-deme diversity even at neutral sites distant from the polymorphic locus, producing higher FST values than with no selection. Expand