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INBREEDING DEPRESSION AND ITS EVOLUTIONARY CONSEQUENCES
The harmful effects of close inbreeding have been noticed for many centuries (34, 35, 165). With the rise of Mendelian genetics, it was realized that the main genetic consequence of inbreeding is… Expand
Rates of spontaneous mutation.
Rates of spontaneous mutation per genome as measured in the laboratory are remarkably similar within broad groups of organisms but differ strikingly among groups. Mutation rates in RNA viruses, whose… Expand
The effect of deleterious mutations on neutral molecular variation.
Selection against deleterious alleles maintained by mutation may cause a reduction in the amount of genetic variability at linked neutral sites. This is because a new neutral variant can only remain… Expand
A Model for the Evolution of Dioecy and Gynodioecy
A model for the evolution of gynodioecy from the hermaphrodite or monoecious condition is described, taking into account the effects of partial selfing and inbreeding depression. It is shown that a… Expand
The Relative Rates of Evolution of Sex Chromosomes and Autosomes
We develop models of the rates of evolution at sex-linked and autosomal loci and of the rates of fixation of chromosomal rearrangements involving sex chromosomes and autosomes. We show that the… Expand
Effective population size and patterns of molecular evolution and variation
- B. Charlesworth
- Biology, Medicine
- Nature Reviews Genetics
- 1 March 2009
The effective size of a population, Ne, determines the rate of change in the composition of a population caused by genetic drift, which is the random sampling of genetic variants in a finite… Expand
Evolution in age-structured populations
- B. Charlesworth
- Biology, Mathematics
- 1 September 1983
Preface to first edition Preface to second edition 1. Models of age-structured populations 2. The genetics of populations without selection 3. Selection: construction of a model and the properties of… Expand
The evolutionary dynamics of repetitive DNA in eukaryotes
Repetitive DNA sequences form a large portion of the genomes of eukaryotes. The 'selfish DNA' hypothesis proposes that they are maintained by their ability to replicate within the genome. The… Expand
Steps in the evolution of heteromorphic sex chromosomes
We review some recently published results on sex chromosomes in a diversity of species. We focus on several fish and some plants whose sex chromosomes appear to be ‘young’, as only parts of the… Expand
The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations.
Levels of neutral genetic diversity in populations subdivided into two demes were studied by multilocus stochastic simulations. The model includes deleterious mutations at loci throughout the genome,… Expand