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The sequence of sequencers: The history of sequencing DNA
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Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation.
TLDR
DENV NS5 is a potent and specific type I IFN antagonist, which binds signal transducer and activator of transcription 2 and inhibits its phosphorylation.
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Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases
TLDR
An in vitro model in which human immature DC form long processessimilar to those formed in vivo, found to be dependent on the activity of Rho GTPases and coordinate adhesion and protrusion to perform a specialized process of cellular morphogenesis.
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Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs− HSV Vectors for Dendritic Cell-Mediated…
ABSTRACT Herpes simplex virus (HSV) infects dendritic cells (DC) efficiently but with minimal replication. HSV, therefore, appears to have evolved the ability to enter DC even though they are…
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Neoantigen-directed immune escape in lung cancer evolution
TLDR
It is suggested that the immune microenvironment exerts a strong selection pressure in early-stage, untreated non-small-cell lung cancers that produces multiple routes to immune evasion, which are clinically relevant and forecast poor disease-free survival.
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Herpes simplex virus infection of dendritic cells: balance among activation, inhibition, and immunity.
TLDR
Data support a pathogenetic model of HSV infection, in which initial delay in the generation of immune responses to HSV at peripheral sites is mediated by disruption of DC function but is overcome by bystander DC maturation and cross-presentation ofHSV antigens.
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Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages
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Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis
TLDR
Elevated blood BATF2 transcript levels provide a sensitive biomarker that discriminates active TB from healthy individuals, and a potentially novel 4-gene transcriptional signature differentiates between active TB and other infectious diseases in individuals presenting with fever.
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Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose
TLDR
Analysis of T and B cell responses after first-dose vaccination with the Pfizer/BioNTech messenger RNA vaccine BNT162b2 in health care workers followed longitudinally, with or without prior SARS-CoV-2 infection found enhanced T cell immunity, antibody-secreting memory B cell response to the spike protein, and neutralizing antibodies effective against variants.
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The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation.
TLDR
A central role for CD98 is supported within a multimolecular unit that regulates cell aggregation and 2 antibodies to CD147, an immunoglobulin superfamily member whose function has remained unclear, were also potent inhibitors of both the aggregation and the protein tyrosine phosphorylation induced via CD98 ligation.
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