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Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
TLDR
Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine, indicative of an allergic-type reaction.
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Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity.
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Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.
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Modulation of the Heparanase-inhibiting Activity of Heparin through Selective Desulfation, Graded N-Acetylation, and Glycol Splitting*
TLDR
The combination of high inhibition of heparanase and low release/potentiation of ECM-bound growth factor indicates that N-acetylated, glycol-split heparins are potential antiangiogenic and antimetastatic agents that are more effective than their counterparts with unmodified backbones.
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SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis
TLDR
These results provide mechanistic insight into the antitumor action of SST0001 and validate its use as a novel therapeutic tool for treating multiple myeloma.
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Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences.
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1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding site.
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Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models
TLDR
Results clearly indicate that elevation of heparanase levels in healing wounds markedly accelerates tissue repair and skin survival that are mediated primarily by an enhanced angiogenic response.
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A conductimetric method for the determination of sulphate and carboxyl groups in heparin and other mucopolysaccharides.
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Structure and biological interactions of heparin and heparan sulfate.
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