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The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.
Gcd10p and Gcd14p were found to be subunits of a protein complex with prominent nuclear localization, suggesting a direct role in tRNAiMet maturation, and analysis of base modifications revealed that 1-methyladenosine (m1A) is undetectable in gcd10Delta tRNA.
A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs
- P. Copeland, J. E. Fletcher, B. Carlson, D. Hatfield, D. Driscoll
- Biology, ChemistryThe EMBO journal
- 17 January 2000
It is established that SBP2 is essential for the co‐translational insertion of Sec into selenoproteins and hypothesize that the binding activity of SBp2 may be involved in preventing termination at the UGA/Sec codon.
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.
- B. Carlson, M. Dubay, E. Sausville, L. Brizuela, P. Worland
- Biology, ChemistryCancer research
- 1 July 1996
Inhibition of the CDK4 and/or CDK2 kinase activity by Flavopiridol can account for the G1 arrest observed after exposure to FlavopIRidol.
Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.
- M. Losiewicz, B. Carlson, G. Kaur, E. Sausville, P. Worland
- Biology, ChemistryBiochemical and biophysical research…
- 15 June 1994
L86-8275 directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein.
Decoding apparatus for eukaryotic selenocysteine insertion
expression of the two functional domains of the bacterial elongation factor–SECIS binding protein as two separate proteins in eukaryotes suggests a mechanism for rapid exchange of charged for uncharged selenocysteyl‐tRNA–elongation factor complex, allowing a single SECIS element to serve multiple UGA codons.
Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes
Comparative genomics and experimental analyses revealed that the mammalian Sec synthase (SecS) is the previously identified pyridoxal phosphate‐containing protein known as the soluble liver antigen.
Selenium and selenocysteine: roles in cancer, health, and development.
SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family.
A new protein family is defined that includes mammalian selenoproteins SelW, SelV, SelT and SelH, bacterial SelW-like proteins and cysteine-containing proteins of unknown function in all three domains of life, and a mechanism for redox regulation of the 14-3-3 family of proteins is suggested.
Structure-Expression Relationships of the 15-kDa Selenoprotein Gene
The expression pattern of the 15-kDa protein in normal and malignant tissues, the occurrence of polymorphisms associated with protein expression, the role of selenium in differential regulation of polymorphism, and the chromosomal location of the gene may be relevant to a role of this protein in cancer.
Selenoprotein H Is a Nucleolar Thioredoxin-like Protein with a Unique Expression Pattern*
- S. Novoselov, G. Kryukov, Xue-ming Xu, B. Carlson, D. Hatfield, V. Gladyshev
- BiologyJournal of Biological Chemistry
- 20 April 2007
Sensitive sequence and structure analyses establish SelH as a novel nucleolar oxidoreductase and suggest that some functions in this compartment are regulated by redox and dependent on the trace element selenium.