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20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies
TLDR
Persistency and sensitivity rates in a Danish eczema population are provided and are useful for decisions regarding the standard series.
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Patients with multiple contact allergies: a review
TLDR
The evidence and characteristics of an increased susceptibility factor, possible causes to and genetic markers for the increased susceptibility, composition of the patient group and identification of patients at risk of developing multiple contact allergies are discussed.
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Skin reaction and regeneration after single sodium lauryl sulfate exposure stratified by filaggrin genotype and atopic dermatitis phenotype
Filaggrin is key for the integrity of the stratum corneum. Mutations in the filaggrin gene (FLGnull) play a prominent role in atopic dermatitis (AD) pathogenesis. People with AD have increased…
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Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study
TLDR
It remains unclear whether or not filaggrin gene (FLG) null mutations increase the overall risk of hand eczema or only increase the risk ofHand Eczema in subjects with atopic dermatitis.
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Filaggrin mutations are strongly associated with contact sensitization in individuals with dermatitis
Background. Although heterozygous filaggrin gene (FLG) mutation carriers seem to have an increased risk of atopic, irritant and allergic nickel dermatitis, it remains unclear whether the risk of…
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The prevalence of chromium allergy in Denmark is currently increasing as a result of leather exposure
TLDR
Danish legislation made the addition of ferrous sulphate compulsory in cement to reduce the water‐soluble chromium content to not more than 2 ppm in 1983, and an effect from this intervention has previously been demonstrated among Danish construction workers.
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Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men
TLDR
Evidence is provided that carriers of FLG loss-of-function alleles may have higher internal exposure to phthalates, possibly due to increased transepidermal absorption.
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Associations between baseline allergens and polysensitization
TLDR
Identification of patients at risk of developing polysensitization is not possible at present because of a lack of available data, but an association between weak sensitizers and polysensing has been hypothesized.
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Sites of dermatitis in a patch test population: hand dermatitis is associated with polysensitization
TLDR
This work has shown that a large proportion of polysensitized individuals may have dermatitis in other skin areas, andpolysensitization in larger series of contact allergic patients is rarely reported.
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Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxyvitamin D concentrations.
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