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Comparative Pharmacokinetics of BB-K8 and Kanamycin in Dogs and Humans
TLDR
The kinetic parameters governing the distribution and elimination of BB-K8 and kanamycin after an im dose were similar to those obtained for iv dosing and indicate desirable dose-independent kinetics, according to a human pharmacokinetic study.
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Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection
TLDR
Hypericin given orally in doses of 0.05 and 0.10 mg/kg/d caused considerable phototoxicity and had no detectable anti-HCV activity in patients with chronic HCV infection.
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Multiple-dose pharmacokinetics and bioequivalence of L-carnitine 330-mg tablet versus 1-g chewable tablet versus enteral solution in healthy adult male volunteers.
TLDR
Pharmacokinetic evaluations were found to be powerful tools for bioequivalence determinations; the power to detect 20% differences in AUC, Cmax tmax, and Cmin0 was > 80%.
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A study of the interaction of the hypnotic effects and of the toxic effects of chloral hydrate and ethanol.
TLDR
The synergism between the hypnotic effects of chloral hydrate and ethanol was investigated in male mice by determination of ED5O's and use of the isobolographic method, finding no departures from simple additivity, thus leading to the conclusion that the interaction must be one between chloral Hydrates and ethanol directly.
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Interference with measurements of certain drugs in plasma by a plasticizer in vacutainer tubes.
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Dissolution medium—a critical parameter to identify bioavailability problems of furosemide tablets
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Comparative Pharmacokinetics and Metabolism of Cephapirin in Laboratory Animals and Humans
Comparative drug disposition studies in mice, rats, dogs, and humans indicate that cephapirin, a new semisynthetic cephalosporin antibiotic that exhibits broad-spectrum antimicrobial activity, is…
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Novel drug delivery systems: Fundamentals, developmental concepts, biomedical assessments
Phenotypic Differences in Dextromethorphan Metabolism
TLDR
Ratios of conjugated/free dextrorphan and 3-hydroxymorphinan excreted in the urine suggest also a lack of conjUGative capacity in the PM, relative to the EM.
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Comparison of L-carnitine pharmacokinetics with and without baseline correction following administration of single 20-mg/kg intravenous dose.
TLDR
Baseline correction probably has its greatest value in attempting to determine and/or define the biological half-life and Vdss for the "exogenously" administered dose and uncorrected data best describes the pharmacokinetics of composite endogenous and exogenous L-carnitine levels.
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