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Cell-mediated immunomodulation of chemokine receptor 7-expressing porcine sertoli cells in murine heterotopic heart transplantation.
BACKGROUND Sertoli cells (SC) have immunomodulative properties, and chemokine receptor 7 (CCR7) can optimize the systemic immunomodulatory effect by guiding SC from the periphery to the secondaryExpand
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Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection After Alemtuzumab Treatment
Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody‐mediated mechanismsExpand
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Mechanism of Humoral and Cellular Immune Modulation Provided by Porcine Sertoli Cells
The understanding of main mechanisms that determine the ability of immune privilege related to Sertoli cells (SCs) will provide clues for promoting a local tolerogenic environment. In this study, weExpand
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Systemic immune modulation using chemokine receptor 7 expressing porcine Sertoli cells
Abstract:  Background:  Sertoli cells (SC) are known to have active mechanism for evading humoral immune response and are known to have immune modulatory effects in the presence of other antigens.Expand
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An immunocompetent mouse model of human glioblastoma
Orthotopic xenotransplantation studies represent the final stage in preclinical cancer research and could facilitate the implementation of precision medicine. To date, these xenografts have beenExpand
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A multi-phase transitioning peptide hydrogel for suturing ultra-small vessels
Many surgeries are complicated by the need to anastomose, or reconnect, micron-scale vessels. Although suturing remains the gold standard for anastomosing vessels, it is difficult to place suturesExpand
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Porcine PD‐L1: cloning, characterization, and implications during xenotransplantation
Abstract: Background:  Effective intervention achieved by manipulating cell‐mediated xenogeneic immune responses would critically increase the clinical feasibility of xenotransplantation as immediateExpand
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Role of Complement Regulatory Proteins in the Survival of Murine Allo-transplanted Sertoli Cells
Sertoli cells (SC) are known to contain immunoprotective properties, which allow them to survive as allografts without the use of immunosuppressive drugs. Experiments were designed to determine whichExpand
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An immunocompetent mouse model of human glioblastoma.
Orthotopic xenotransplantation studies represent the final stage in preclinical cancer research and could facilitate the implementation of precision medicine. To date, these xenografts have beenExpand
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Establishment and characterization of porcine Sertoli cell line for the study of xenotransplantation
Abstract:  Background:  An understanding of the main mechanism that determines the ability of immune privilege related to Sertoli cells (SC) will provide clues for promoting a local tolerogenicExpand
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