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Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.
Dihydropyrimidine 12a is both more potent and longer acting than nifedipine and compares most favorably with the long-acting dihydropyridine derivative amlodipine in vitro and has the potential advantage of being a single enantiomer in vivo. Expand
Development of a Safe and Scalable Oxidation Process for the Preparation of 6-Hydroxybuspirone: Application of In-Line Monitoring for Process Ruggedness and Product Quality
A mechanistic understanding of how key process factors affected product quality led to the successful application of FTIR as a process analytical technology (PAT) tool and enabled real time quality assurance and the development of an effective and efficient manufacturing process. Expand
Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents.
The results demonstrate that the active R-(-)-enantiomer 20a of 7 is both more potent and longer acting than nifedipine (1) as an antihypertensive agent in the SHR. Expand
Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidines
Par reactions electrophiles selectives sur les [p-anisilyloxy-2- ou p-anisylthio-2 dihydro-1,4 nitro-3'phenyl-4 methyl-6] pyrimidinecarboxylates-5 d'ethyle, obtention d'[oxo-2- ou thioxo-2Expand
A facile synthesis of cyanoguanidines from thioureas
Abstract A facile synthesis of cyanoguanidines from corresponding thioureas is reported using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (water soluble carbodiimide).
Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects.
Extensive pharmacological testing of selected compounds indicated that aminonaphthols are antihypertensive agents with many pharmacological properties. Expand