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Epithelial to Mesenchymal Transition induces cell cycle arrest and parenchymal damage in renal fibrosis
Kidney fibrosis is marked by an epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells (TECs). Here we find that, during renal fibrosis, TECs acquire a partial EMT program duringExpand
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Transport of organic anions across the basolateral membrane of proximal tubule cells.
Renal proximal tubules secrete diverse organic anions (OA) including widely prescribed anionic drugs. Here, we review the molecular properties of cloned transporters involved in uptake of OA fromExpand
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Identification of a New Urate and High Affinity Nicotinate Transporter, hOAT10 (SLC22A13)*
The orphan transporter hORCTL3 (human organic cation transporter like 3; SLC22A13) is highly expressed in kidneys and to a weaker extent in brain, heart, and intestine. hORCTL3-expressing XenopusExpand
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In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy.
Organic anion transporters 1-10 (OAT1-10) and the urate transporter 1 (URAT1) belong to the SLC22A gene family and accept a huge variety of chemically unrelated endogenous and exogenous organicExpand
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Electrically silent cotransport on Na+, K+ and Cl- in Ehrlich cells.
A cotransport system for Na+, K+ and Cl- in Ehrlich cells is described. It is insensitive towards ouabain but specifically inhibited by furosemide and other 'high ceiling' diuretics at concentrationsExpand
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Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function.
Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1,Expand
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Pelizaeus–Merzbacher-like disease is caused not only by a loss of connexin47 function but also by a hemichannel dysfunction
Autosomal recessive mutations in the GJA12/GJC2 gene encoding the gap junction protein connexin47 (C × 47) cause a form of Pelizaeus–Merzbacher-like disease (PMLD) with hypomyelination, nystagmus,Expand
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Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions.
Proximal tubule cells extract dicarboxylates from filtrate and blood, using cotransporters located in the brush border [sodium dicarboxylate cotransporter (NaDC-1)] and basolateral cell membraneExpand
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Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues.
The role of proximal versus distal tubular injury in the pathogenesis of acute kidney injury (AKI) is debatable. Inhibition of prolyl hydroxylases that regulate the degradation of hypoxia-inducibleExpand
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Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions.
Tubular reabsorption of sulfate is achieved by the sodium-dependent sulfate transporter, NaSi-1, located at the apical membrane, and the sulfate-anion exchanger, sat-1, located at the basolateralExpand
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