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Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin
The purpose of the present investigation was to examine the topographical organization of efferent projections from the cytoarchitectonic divisions of the mPFC (the medial precentral, dorsal anteriorExpand
The control of firing pattern in nigral dopamine neurons: burst firing
  • A. Grace, B. Bunney
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 November 1984
TLDR
The data suggest that the increased calcium influx accompanying an increased firing rate triggers burst firing, possibly by inactivating a potassium conductance. Expand
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
TLDR
The determination of the electrophysiological characteristics of a population of cells directly identified as containing a specific neurotransmitter may allow one to construct better models of a system's functioning and may be important functionally with respect to a possible modulatory effect of dopamine in postsynaptic target areas. Expand
The control of firing pattern in nigral dopamine neurons: single spike firing
  • A. Grace, B. Bunney
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 November 1984
TLDR
In vivo intracellular injection of the calcium chelator EGTA will cause DA cells to fire in a regular, pacemaker pattern, with the amplitude of the afterhyperpolarization being proportional to the number of spikes in a train. Expand
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
  • L. Chiodo, B. Bunney
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 August 1983
TLDR
It is suggested that the time-dependent development of A9 DA neuron inactivation induced by repeated neuroleptic treatment may provide a mechanism for understanding the delayed onset of extrapyramidal side effects often observed with antipsychotic drugs. Expand
Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine
TLDR
Perfusion with solutions containing the ionic composition of commercially available Ringer's solution, which mimic the ional composition of plasma as opposed to brain extracellular fluid, alters the turnover rate and basal release of dopamine. Expand
Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat
TLDR
Evidence is provided of amygdalar control of stress-induced metabolic activation of the monoaminergic systems in the m-PFC, as well as amygdAlar integration of behavioral and neuroendocrine components of the rat stress response. Expand
Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.
TLDR
Direct evidence is provided for structural alterations in VTA dopamine neurons as a consequence of chronic opiate exposure, which could contribute to changes in mesolimbic dopamine function associated with addiction. Expand
Paradoxical GABA excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons.
  • A. Grace, B. Bunney
  • Chemistry, Medicine
  • European journal of pharmacology
  • 16 November 1979
TLDR
The data suggest that ZC cells receive an inhibitory GABAergic input from ZR cells that are in turn inhibited by low doses of GABA agonists, which would account for the "paradoxical" excitatory effect ofGA agonists on ZC neuron activity. Expand
Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
TLDR
The data suggest that different classes of antipsychotic drugs may have distinct effects on the release of dopamine from the nigrostriatal, mesolimbic, and mesocortical terminals. Expand
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