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The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers.
TLDR
A serine/proline rich site, which can be phosphorylated by kinases in developing muscle tissues, was identified near the amino terminus of titin and sequence analysis revealed the presence of a novel 45 residue repeat ('Z-repeats') in this region of the molecule. Expand
Kettin, a large modular protein in the Z‐disc of insect muscles.
TLDR
It is suggested that the protein acts as scaffolding in the Z‐disc and is called kettin, which may cause disintegration of the Z-disc and alpha‐actinin release which lead to disassembly of the myofibril. Expand
Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility.
TLDR
This work has investigated splicing pathways of the sls gene and identified isoforms expressed in different muscle types, and at different stages of Drosophila development, which could regulate the stiffness of the many fibre types in Drosophile muscles. Expand
Troponin of asynchronous flight muscle.
TLDR
Electron micrographs of negatively stained specimens showed that Lethocerus thin filaments have projections at about 39 nm intervals, which are not seen on thinfilaments from vertebrate striated muscle and are probably due to the relatively large troponin complex. Expand
Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products.
TLDR
The crystal structure of Drosophila glutathione S-transferase-2 is reported and a structure-based model of 4-HNE binding is presented, suggesting that residues Y208, R145 and possibly Y153 may be key residues involved in catalysis. Expand
Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect.
TLDR
It is suggested that initial activation of IFM is by Ca(2+) binding to troponin with the two-site TnC, and full activation is through the action of stretch on the complex with the one-site isoform. Expand
Identification and localization of high molecular weight proteins in insect flight and leg muscle.
TLDR
Preliminary DNA sequencing shows that p800 is related to vertebrate titin and nematode twitchin, and all three high molecular weight proteins probably stabilize the structure of the myofibril. Expand
Flightin Is Essential for Thick Filament Assembly and Sarcomere Stability in Drosophila Flight Muscles
TLDR
The results indicate that flightin is required for the establishment of normal thick filament length during late pupal development and thick filament stability in adult after initiation of contractile activity. Expand
Kettin, a major source of myofibrillar stiffness in Drosophila indirect flight muscle
TLDR
It is concluded that kettin is attached not only to actin but also to the end of the thick filament, which may constitute the elastic filament system of insect IFM and determine the muscle's high stiffness necessary for stretch activation. Expand
Association of the Chaperone αB-crystallin with Titin in Heart Muscle*
TLDR
Reversible association with αB-crystallin would protect I-band titin from stress liable to cause domain unfolding until conditions are favorable for refolding to the native state. Expand
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