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The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity.
- Yukihiro Kaneko, Matthew Thoendel, O. Olakanmi, B. Britigan, P. Singh
- Medicine, Biology
- The Journal of clinical investigation
- 2 April 2007
A novel antiinfective approach is to exploit stresses already imposed on invading organisms by the in vivo environment. Fe metabolism is a key vulnerability of infecting bacteria because organisms… Expand
Role of oxidants in microbial pathophysiology.
Reactive oxidant species (superoxide, hydrogen peroxide, hydroxyl radical, hypohalous acid, and nitric oxide) are involved in many of the complex interactions between the invading microorganism and… Expand
Oxidative Responses of Human and Murine Macrophages During Phagocytosis of Leishmania chagasi1
Leishmania chagasi, the cause of South American visceral leishmaniasis, must survive antimicrobial responses of host macrophages to establish infection. Macrophage oxidative responses have been shown… Expand
Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells.
- Y. O’Malley, K. Reszka, D. Spitz, G. Denning, B. Britigan
- Biology, Medicine
- American journal of physiology. Lung cellular and…
- 1 July 2004
Production of pyocyanin enhances Pseudomonas aeruginosa virulence. Many of pyocyanin's in vitro and in vivo cytotoxic effects on human cells appear to result from its ability to redox cycle.… Expand
Modulation of lung epithelial functions by Pseudomonas aeruginosa.
Microorganisms gain access to the airways and respiratory epithelial surface during normal breathing. Most inhaled microbes are trapped on the mucous layer coating the nasal epithelium and upper… Expand
Free radicals and phagocytic cells
- G. Rosen, S. Pou, Carroll L. Ramos, M. Cohen, B. Britigan
- Medicine, Chemistry
- FASEB journal : official publication of the…
- 1 February 1995
Phagocytes mediate their innate immunological response by releasing products that damage invading microorganisms. These products include proteins such as lysozyme, peroxidases, and elastase as well… Expand
Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes.
- Carroll L. Ramos, S. Pou, B. Britigan, M. S. Cohen, G. Rosen
- Chemistry, Medicine
- The Journal of biological chemistry
- 25 April 1992
Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN,… Expand
Gallium Disrupts Iron Metabolism of Mycobacteria Residing within Human Macrophages
ABSTRACT Mycobacterium tuberculosis and M. aviumcomplex (MAC) enter and multiply within monocytes and macrophages in phagosomes. In vitro growth studies using standard culture media indicate that… Expand
Pseudomonas Pyocyanin Increases Interleukin-8 Expression by Human Airway Epithelial Cells
- G. Denning, L. A. Wollenweber, M. A. Railsback, C. Cox, L. L. Stoll, B. Britigan
- Biology, Medicine
- Infection and Immunity
- 1 December 1998
ABSTRACT Pseudomonas aeruginosa, an opportunistic human pathogen, causes acute pneumonia in patients with hospital-acquired infections and is commonly associated with chronic lung disease in… Expand
Hepatitis C virus‐core and non structural proteins lead to different effects on cellular antioxidant defenses
- M. Y. Abdalla, I. Ahmad, D. Spitz, W. Schmidt, B. Britigan
- Medicine, Biology
- Journal of medical virology
- 1 August 2005
Chronic hepatitis C virus (HCV) infection leads to increased oxidative stress in the liver. Hepatic antioxidant enzymes provide an important line of defense against oxidative injury. To understand… Expand