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Criteria for the diagnosis of corticobasal degeneration
Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologicExpand
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Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can cause neurodegeneration remains controversial. Here, we use transcriptome profiling to demonstrate thatExpand
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Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
Low frequency coding variants in TREM2 are associated with increased Alzheimer disease (AD) risk, while loss of functions mutations in the gene lead to an autosomal recessive early-onset dementia,Expand
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Identification of common variants influencing risk of the tauopathy Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which isExpand
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Mutation within TARDBP leads to Frontotemporal Dementia without motor neuron disease
It has been recently demonstrated that the 43‐kDa transactive response (TAR)‐DNA‐binding protein (TARDBP) is the neuropathological hallmark of Frontotemporal Dementia (FTD) with ubiquitin‐positiveExpand
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Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
Relating clinical symptoms to neuroanatomical profiles of brain damage and ultimately to tissue pathology is a key challenge in the field of neurodegenerative disease and particularly relevant to theExpand
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MCI conversion to dementia and the APOE genotype
Objectives: To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairmentExpand
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Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD
Granulin (GRN) mutations have been identified as a major cause of frontotemporal lobar degeneration (FTLD) by haploinsufficiency mechanism, although their effects on brain tissue dysfunction andExpand
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Genetic correlates of behavioral endophenotypes in Alzheimer disease: Role of COMT, 5-HTTLPR and APOE polymorphisms
Several studies have been conducted to understand the genetic correlates of Alzheimer disease (AD)-related behavioral and psychological symptoms in dementia (BPSD). However, given that BPSD rarelyExpand
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Treatment of primary progressive aphasias by transcranial direct current stimulation combined with language training.
BACKGROUND Primary progressive aphasia (PPA) is an untreatable neurodegenerative disorder that disrupts language functions. Previous studies have demonstrated transcranial direct current stimulationExpand
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