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The organization of recent and remote memories
Recent studies have begun to shed light on how remote memories are organized in the cortex, and the molecular and cellular events that underlie their consolidation.
The Involvement of the Anterior Cingulate Cortex in Remote Contextual Fear Memory
- P. Frankland, B. Bontempi, L. E. Talton, L. Kaczmarek, Alcino J. Silva
- Biology, PsychologyScience
- 7 May 2004
Although the molecular, cellular, and systems mechanisms required for initial memory processing have been intensively investigated, those underlying permanent memory storage remain elusive. We…
Sites of Neocortical Reorganization Critical for Remote Spatial Memory
Consolidation of spatial memory requires a time-dependent hippocampal-cortical dialogue, ultimately enabling widespread cortical networks to mediate effortful recall and use of cortically stored remote memories independently.
Memory formation and long-term retention in humans and animals: Convergence towards a transformation account of hippocampal–neocortical interactions
Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory
- Edith Lesburguères, O. Gobbo, S. Alaux-Cantin, Anne Hambucken, P. Trifilieff, B. Bontempi
- Biology, PsychologyScience
- 18 February 2011
Evidence is presented that neurons in the rat cortex must undergo a “tagging process” upon encoding to ensure the progressive hippocampal-driven rewiring of cortical networks that support remote memory storage.
Time-dependent reorganization of brain circuitry underlying long-term memory storage
There is a time-dependent reorganization of the neuronal circuitry underlying long-term memory storage, in which a transitory interaction between the hippocampal formation and the neocortex would mediate the establishment of long-lived cortical memory representations.
Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory
- S. Trouche, B. Bontempi, P. Roullet, C. Rampon
- Biology, PsychologyProceedings of the National Academy of Sciences
- 7 April 2009
This work shows that new neurons in the DG are recruited into neuronal networks that support retrieval of remote spatial memory and that their activation is situation-specific, and reveals that once selected, new hippocampal neurons are durably incorporated into memory circuits, and also that their recruitment into hippocampal networks contributes predominantly to the updating and strengthening of a previously encoded memory.
The Formation of Recent and Remote Memory Is Associated with Time-Dependent Formation of Dendritic Spines in the Hippocampus and Anterior Cingulate Cortex
- L. Restivo, G. Vetere, B. Bontempi, M. Ammassari-Teule
- Biology, PsychologyThe Journal of Neuroscience
- 24 June 2009
The findings reveal that gradual structural changes modifying connectivity in hippocampal–cortical networks underlie the formation and expression of remote memory, and that the hippocampus plays a crucial but time-limited role in driving structural plasticity in the cortex.
Systemic Morphine-Induced Fos Protein in the Rat Striatum and Nucleus Accumbens Is Regulated by μ Opioid Receptors in the Substantia Nigra and Ventral Tegmental Area
Fos induction in dorsomedial striatum after systemic administration of morphine seems to be mediated by dopamine neurons in medial SN and VTA that project to medial striatum and NAc, respectively.
Selective Erasure of a Fear Memory
The results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace, and identifies them as lateral amygdala neurons with increased cyclic adenosine monophosphate response element–binding protein (CREB).