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In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria.
Identification of Peptaibols from Trichoderma virens and Cloning of a Peptaibol Synthetase*
- A. Wiest, D. Grzegorski, C. Kenerley
- Biology, ChemistryThe Journal of Biological Chemistry
- 7 June 2002
Preliminary characterization of a 62.8-kb continuous open reading frame encoding a peptaibol synthetase from T. virens shows the predicted protein structure consists of 18 peptide synthetases modules with additional modifying domains at the N- and C-termini.
Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam.
Antimicrobial and cytotoxic agents from Calophyllum inophyllum.
Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda.
Cell wall synthesis is a major target of mycoparasitic antagonism by Trichoderma harzianum
Cell wall turnover is identified as a major target of mycoparasitic antagonism because of an inhibition of the membrane-bound beta-1,3-glucan synthase of the host by the peptaibols, which inhibit the resynthesis of cell wall beta- glucans, sustain the disruptive action of beta-Glucanases, and all together enhance the fungicidal activity.
Cytotoxic and antimicrobial coumarins from Mammea africana
- B. M. Ouahouo, A. Azebaze, M. Meyer, B. Bodo, Z. Fomum, A. E. Nkengfack
- ChemistryAnnals of tropical medicine and parasitology
- 1 October 2004
All the coumarin compounds showed noteworthy cytotoxicity against the human 9-KB cell line and both of the 4-n-propylcoumarins were also found to exhibit significant activity against Staphylococcus aureus.
A flavone and an unusual 23-carbon terpenoid from Andrographis paniculata.
Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees.
Globulixanthones A and B, two new cytotoxic xanthones with isoprenoid groups from the root bark of Symphonia globulifera.
- A. E. Nkengfack, P. Mkounga, Z. Fomum, M. Meyer, B. Bodo
- ChemistryJournal of natural products
- 10 April 2002
Bioassay-guided fractionation of a root bark extract of Symphonia globulifera has yielded two new xanthones with isoprenoid units, named globulixanthones A and B, which possess significant cytotoxicity in vitro against the KB cell line.