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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
The properties and putative relationship of these two amino acid exchangers are discussed in the context of their demonstrated utility in cancer biology, including cellular growth and survival signaling and integrated links to the mammalian target-of-rapamycin (mTOR) kinase. Expand
Recent molecular advances in mammalian glutamine transport.
  • B. Bode
  • Biology, Medicine
  • The Journal of nutrition
  • 1 September 2001
Much has been learned about plasma membrane glutamine transporter activities in health and disease over the past 30 years, including their potential regulatory role in metabolism. Since the 1960s,Expand
ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.
The results suggest that ASCT2 silencing inhibits mTORC1 signaling to the translational machinery followed by an m TORC2-initiated survival response, establishing a link between amino acid transporter expression and mTOR function. Expand
An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma
Results indicate that replication‐competent HSV1 mutants hold significant promise as cancer therapeutic agents, suggesting that viral oncolysis and not the host immune response is the primary mechanism of tumor destruction. Expand
Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells.
  • B. Bode, B. Fuchs, +6 authors W. Souba
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal…
  • 1 November 2002
The growth of all hepatomas was glutamine dependent, and competitive inhibition of ATB(0)-mediated glutamine uptake blocked proliferation only in poorly differentiated cells lacking SN1 or SN2 expression and exhibiting low glutamine synthetase mRNA levels. Expand
Stressing out over survival: glutamine as an apoptotic modulator.
  • B. Fuchs, B. Bode
  • Biology, Medicine
  • The Journal of surgical research
  • 1 March 2006
INTRODUCTION The amino acid glutamine (GLN) has received considerable attention as a potential therapeutic adjuvant in critical illness and in improving postoperative clinical outcomes. Most studiesExpand
Modulation of Cellular Proliferation Alters Glutamine Transport and Metabolism in Human Hepatoma Cells
Hepatocellular transformation is characterized by a marked increase in glutamine transport and metabolism, indicating that inhibition of cellular proliferation similarly affects disparate amino acid transporters. Expand
Arginine transport in human liver. Characterization and effects of nitric oxide synthase inhibitors.
Data indicate that arginine transport by human hepatocytes is mediated primarily by the Na(+)-independent transport System y+, which may be a metabolic strategy that can be used to modulate the septic response. Expand
Amino acid-dependent increase in hepatic system N activity is linked to cell swelling.
It is demonstrated that cell swelling is a prerequisite for the amino acid-dependent activation of the hepatic System N transporter, indicating that active accumulation of amino acids via Na(+)-dependent carriers is necessary for the activation to occur. Expand
Glucocorticoids regulate rat glutamine synthetase expression in a tissue-specific manner.
Comparison of Northern and Western blotting results revealed a dichotomy in the ratio of relative GS mRNA and protein level in rat organs, suggesting that tissue-specific posttranscriptional processes determine GS protein levels. Expand