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Methods of in vitro toxicology.
This paper reviews the state of the art, future potential, research needs and the hazard assessment of food-associated chemicals using established and novel in vitro toxicological approaches. Expand
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A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.
Systemic toxicity testing forms the cornerstone for the safety evaluation of substances. Pressures to move from traditional animal models to novel technologies arise from various concerns, including:Expand
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Biokinetic Modeling and in Vitro–in Vivo Extrapolations
  • B. Blaauboer
  • Chemistry, Medicine
  • Journal of toxicology and environmental health…
  • 17 June 2010
The introduction of in vitro methodologies in the toxicological risk assessment process requires a number of prerequisites regarding both the toxicodynamics and the biokinetics of the compounds underExpand
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Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo dose extrapolations.
Challenges to improve toxicological risk assessment to meet the demands of the EU chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have accelerated the developmentExpand
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The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.
At present, regulatory assessment of systemic toxicity is almost solely carried out using animal models. The European Commission's REACH legislation stimulates the use of animal-free approaches toExpand
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Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro.
The potency of indole-3-carbinol (I3C) to form condensation products under acidic aqueous conditions was studied. After identifying a known dimer, 3,3'-diindolylmethane (DIM), we elucidated theExpand
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Quantifying processes determining the free concentration of phenanthrene in Basal cytotoxicity assays.
Difficulties may arise when extrapolating in vitro derived toxicity data to in vivo toxicity data because of the high variability and occasional low sensitivity of in vitro results. Differences inExpand
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The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers.
Changes in the isoenzyme pattern of cytochrome P450 during culture were investigated in primary cultures of rat hepatocytes, measuring specific enzyme activities in microsomes prepared from culturedExpand
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Quantification of human hepatic glutathione S-transferases.
Human hepatic glutathione S-transferase (GST) subunits were characterized and quantified with the aid of a recently developed h.p.l.c. method. In 20 hepatic tissue specimens the absolute amounts ofExpand
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