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GABAB-receptor subtypes assemble into functional heteromeric complexes
B-type receptors for the neurotransmitter GABA (γ-aminobutyric acid) inhibit neuronal activity through G-protein-coupled second-messenger systems, which regulate the release of neurotransmitters and… Expand
Molecular structure and physiological functions of GABA(B) receptors.
GABA(B) receptors are broadly expressed in the nervous system and have been implicated in a wide variety of neurological and psychiatric disorders. The cloning of the first GABA(B) receptor cDNAs in… Expand
Molecular Structure and Physiological Functions of GABAB Receptors
GABAB receptors are broadly expressed in the nervous system and have been implicated in a wide variety of neurological and psychiatric disorders. The cloning of the first GABAB receptor cDNAs in 19...
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
GABA (gamma-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABA(A)/ GABA(c)) and metabotropic (GABA(B)) receptor systems. Here we report the… Expand
Cloning of a novel glutamate receptor subunit, GluR5: Expression in the nervous system during development
- B. Bettler, J. Boulter, I. Hermans-Borgmeyer, A. O'Shea-Greenfield, S. Heinemann
- Medicine, Biology
- 1 November 1990
We have isolated cDNAs encoding a glutamate receptor subunit, designated GluR5, displaying 40%-41% amino acid identity with the kainate/AMPA receptor subunits GluR1, GluR2, GluR3, and GluR4. This… Expand
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
l-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain, acts on three classes of ionotropic receptors: NMDA (N-methyl-d-aspartate), AMPA… Expand
Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors
GABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we report the cloning of… Expand
GABAB receptors - the first 7TM heterodimers.
- F. Marshall, K. Jones, K. Kaupmann, B. Bettler
- Medicine, Biology
- Trends in pharmacological sciences
- 1 October 1999
Evidence supports the existence of pharmacological subtypes of GABAB receptors24xKerr, D.I.B. and Ong, J. Pharmacol. Ther. 1995; 67: 187–246Crossref | PubMed | Scopus (192)See all References24. At… Expand
Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity
- L. Lindemann, C. A. Meyer, +8 authors M. Hoener
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 March 2008
The recent identification of the trace amine-associated receptor (TAAR)1 provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-mediated effects.… Expand
The GABAB1b Isoform Mediates Long-Lasting Inhibition of Dendritic Ca2+ Spikes in Layer 5 Somatosensory Pyramidal Neurons
The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular… Expand