• Publications
  • Influence
DNA replication specificity of TYLCV geminivirus is mediated by the amino‐terminal 116 amino acids of the Rep protein
Geminiviruses are plant DNA viruses replicating by a rolling circle mechanism. We have investigated the specificity of replication origin recognition of two different isolates of tomato yellow leafExpand
  • 80
  • 5
Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia
Glutathione (GSH) is the main non-protein antioxidant and plays a critical role in protecting cells from damage by reactive oxygen species (ROS) generated by dopamine (DA) metabolism. We reported aExpand
  • 115
  • 4
Glutamate-induced homocysteic acid release from astrocytes: possible implication in glia-neuron signaling
Glial cells synthesise neuroactive substances and release them upon neurotransmitter receptor activation. Homocysteic acid (HCA), an endogenous agonist for glutamatergic N-methyl-D-aspartate (NMDA)Expand
  • 57
  • 4
Glutamate‐induced Release of the Nitric Oxide Precursor, Arginine, From Glial Cells
Arginine, the nitric oxide precursor, is predominantly localized in glial cells, whereas the constitutive nitric oxide synthase is mainly found in neurons. Therefore, a transfer of arginine fromExpand
  • 47
  • 2
Nitric oxide precursor arginine and S-nitrosoglutathione in synaptic and glial function.
In the last few years, there has been an important increase in interest in nitric oxide (NO) as an intercellular messenger, and its putative role in numerous CNS functions is being continuallyExpand
  • 47
  • 2
β‐Adrenergic Stimulation Promotes Homocysteic Acid Release from Astrocyte Cultures: Evidence for a Role of Astrocytes in the Modulation of Synaptic Transmission
Abstract: The sulfur‐containing amino acid homocysteic acid (HCA) is present in and released from nervous tissue, exerting excitatory effects on neurons by predominantly activating NMDA receptors. ItExpand
  • 55
  • 2
Glial‐Neuronal Transfer of Arginine and S‐Nitrosothiols in Nitric Oxide Transmission
Abstract: The arginine‐nitric oxide (Arg‐NO) and the S‐nitrosothiols systems, two less well‐studied aspects of NO transmission in the central nervous system, are reviewed. A growing body of evidenceExpand
  • 17
  • 1
Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines
SummaryVerapamil, a calcium channel blocker, is used as the racemate. Recently, racemic verapamil has been shown to increase the cytotoxicity of vinca alkaloid and anthracycline derivatives inExpand
  • 35
Novel mode of nitric oxide neurotransmission mediated via S‐nitroso‐cysteinyl‐glycine
S‐nitroso‐cysteinyl‐glycine, a novel nitric oxide‐adduct thiol compound, can be detected in the brain (2.3 ± 0.6 pmol/mg protein), and released following stimulation of sensory afferents to the ratExpand
  • 17
Glial‐derived arginine, the nitric oxide precursor, protects neurons from NMDA‐induced excitotoxicity
Excitotoxic neuronal cell death is characterized by an overactivation of glutamate receptors, in particular of the NMDA subtype, and the stimulation of the neuronal nitric oxide synthase (nNOS),Expand
  • 28