B. Benigno

Publications80
h-index27
Citations2,741
Highly Influential Citations95
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Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells
BackgroundAccumulating evidence suggests that somatic stem cells undergo mutagenic transformation into cancer initiating cells. The serous subtype of ovarian adenocarcinoma in humans has been… Expand
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Laparoscopic radical hysterectomy with paraaortic and pelvic node dissection.
We report the first case of a laparoscopic radical hysterectomy and paraaortic and pelvic lymphadenectomy to treat a stage IA2 carcinoma of the cervix. To our knowledge, a laparoscopic radical… Expand
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Ovarian cancer detection from metabolomic liquid chromatography/mass spectrometry data by support vector machines
TLDR
We evaluate the performance of support vector machines (SVM) for the classification of liquid chromatography/time-of-flight mass spectrometry (LC/TOF MS) metabolomic data focusing on recognizing combinations or "panels" of potential metabolic diagnostic biomarkers. Expand
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Emerging roles for PAX8 in ovarian cancer and endosalpingeal development.
OBJECTIVES Epithelial ovarian carcinomas develop from ovarian surface epithelia that undergo complex differentiation to form distinguishable phenotypes resembling those of the epithelia of the female… Expand
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Phase III trial of intraperitoneal therapy with yttrium-90-labeled HMFG1 murine monoclonal antibody in patients with epithelial ovarian cancer after a surgically defined complete remission.
PURPOSE This was a multinational, open-label, randomized phase III trial comparing yttrium-90-labeled murine HMFG1 (90Y-muHMFG1) plus standard treatment versus standard treatment alone in patients… Expand
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Molecular Profiling Predicts the Existence of Two Functionally Distinct Classes of Ovarian Cancer Stroma
Although stromal cell signaling has been shown to play a significant role in the progression of many cancers, relatively little is known about its importance in modulating ovarian cancer development.… Expand
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The microbiology and therapy of acute pelvic inflammatory disease in hospitalized patients.
We examined microbial isolates from the endocervical and peritoneal cavity of 30 women hospitalized with acute PID. Patients were randomly assigned to one of two antibiotic regimens: amoxicillin, 6… Expand
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L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas
Wide-spread hypomethylation of CpG dinucleotides is characteristic of many cancers. Retrotransposons have been identified as potential targets of hypomethylation during cellular transformation. We… Expand
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Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
BackgroundA large percentage of patients with recurrent ovarian cancer develop resistance to the taxane class of chemotherapeutics. While mechanisms of resistance are being discovered, novel… Expand
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Rapid Mass Spectrometric Metabolic Profiling of Blood Sera Detects Ovarian Cancer with High Accuracy
Background: Ovarian cancer diagnosis is problematic because the disease is typically asymptomatic, especially at the early stages of progression and/or recurrence. We report here the integration of a… Expand
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