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Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial
TLDR
The TOAST stroke subtype classification system is easy to use and has good interobserver agreement and should allow investigators to report responses to treatment among important subgroups of patients with ischemic stroke. Expand
Baseline NIH Stroke Scale score strongly predicts outcome after stroke
TLDR
The baseline National Institutes of Health Stroke Scale (NIHSS) score strongly predicts the likelihood of a patient’s recovery after stroke, and only the TOAST subtype of lacunar stroke predicts outcomes independent of the NIHSS score. Expand
Antithrombotic treatment of ischemic stroke among patients with occlusion or severe stenosis of the internal carotid artery
TLDR
Early identification by duplex imaging of an occlusion or severe stenosis of the ICA ipsilateral to a hemispheric ischemic stroke might improve selection of patients who could be treated with emergent anticoagulation. Expand
Interphysician agreement in the diagnosis of subtypes of acute ischemic stroke
TLDR
Refinement of algorithms for determining subtype of ischemic stroke do improve interphysician agreement, but despite using subtype definitions and being given extensive information often not available in the acute setting, physicians still disagree about the etiology of stroke. Expand
Silent cerebral infarction in patients enrolled in the TOAST study
To determine the frequency, location, size, and risk factors for silent cerebral infarctions (SCIs) on brain CT, we identified 629 patients without a history of previous stroke who were enrolled in aExpand
Design of the Trial of Org 10172 in Acute Stroke Treatment (TOAST).
TLDR
During the design of TOAST, the investigators addressed several issues so the trial could test the treatment accurately, and the strategies used in designing, implementing, and coordinating the trial are reported. Expand
Effect of Prior Aspirin Use on Stroke Severity in the Trial of Org 10172 in Acute Stroke Treatment (TOAST)
TLDR
Aspirin use is associated with milder clinical deficits at stroke onset and may affect prognosis and influence response to treatment, which should ensure that prestroke aspirin use is comparable in study groups. Expand
CNS pseudovasculitis in a patient with pheochromocytoma
TLDR
A patient with angiographic findings resembling CNS vasculitis (CNS pseudovasculitis) who was found to have a pheochromocytoma is reported, which should be included in the differential diagnosis of angiography findings suggestive of CNS Vasculitis. Expand
Stroke in young adults and children
TLDR
The major causes of stroke in young adults and children under 15 years of age are identified and lifestyle choices (eg, cigarette smoking, alcohol consumption, and illicit drug use) can significantly increase the rate of stroke among young adults in a community. Expand
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