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The cholinergic hypothesis of geriatric memory dysfunction.
Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made toExpand
A simple and reliable conflict procedure for testing anti-anxiety agents
The results indicated that this simple procedure clearly demonstrated “anti-anxiety” (i.e., increases in punished responding) effects with benzodiazepines, meprobamate and pentobarbital. Expand
Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor.
The ability of DOV 21,947 to inhibit the reuptake of three biogenic amines closely linked to the etiology of depression may result in a therapeutic profile different from antidepressants that inhibit theReptake of serotonin and/or norepinephrine. Expand
Animal Tests of Anxiety
This unit presents protocols for the most commonly used animal tests of anxiety, including the Geller‐Seifter conflict test, the social interaction test, light/dark exploration, the elevated plus‐maze, defensive burying, and the thirsty rat conflict. Expand
Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.
It is reported that the pyrazolo[1,5-a]-pyrimidine, ocinaplon, exhibits an anxioselective profile in both preclinical procedures and in patients with generalized anxiety disorder, the most common of the anxiety disorders. Expand
A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxiety
CL 218,872 is the first non-benzodiazepine to selectively displace brain specific 3H-diazepam binding with a potency comparable to that of the benzodiazepines. Like the benzodiazepines, CL 218,872Expand
"Broad spectrum" antidepressants: is more better for the treatment of depression?
Based on the pivotal role proposed for dopamine in depression, it has been hypothesized that a broad spectrum antidepressant will produce a more rapid onset and/or higher efficacy than agents inhibiting the reuptake of serotonin and or norepinephrine. Expand
Interleukin-1 stimulates the beta-amyloid precursor protein promoter
It is shown here that this promoter is inducible in cultured cells by interleukin-1 (IL-1) in a transient assay system and that the HSE and AP-1 binding site are required for this inducibility. Expand
Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors
Several new lines of evidence suggest the existence of two or more distinct types of benzodiazepine receptors, in contrast to earlier results suggesting the presence of only one class of receptors.Expand
Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control.
The results suggest that ligand binding to mitochondrial benzodiazepine receptors results in inhibition of mitochondrial respiratory control, which may help to explain the pleiotropic effects of receptor ligands on intact cells. Expand