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The cholinergic hypothesis of geriatric memory dysfunction.
Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made to…
A simple and reliable conflict procedure for testing anti-anxiety agents
The results indicated that this simple procedure clearly demonstrated “anti-anxiety” (i.e., increases in punished responding) effects with benzodiazepines, meprobamate and pentobarbital.
Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor.
Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.
- A. Lippa, P. Czobor, P. Skolnick
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 17 May 2005
It is reported that the pyrazolo[1,5-a]-pyrimidine, ocinaplon, exhibits an anxioselective profile in both preclinical procedures and in patients with generalized anxiety disorder, the most common of the anxiety disorders.
Animal Tests of Anxiety
- S. File, A. Lippa, B. Beer, Morgen T. Lippa
- Psychology, BiologyCurrent Protocols in Pharmacology
- 1 December 2004
This unit presents protocols for the most commonly used animal tests of anxiety, including the Geller‐Seifter conflict test, the social interaction test, light/dark exploration, the elevated plus‐maze, defensive burying, and the thirsty rat conflict.
A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxiety
Age-related differences in behavior across the life span of the C57BL/6J mouse.
- R. Dean, J. Scozzafava, J. A. Goas, B. Regan, B. Beer, R. Bartus
- Psychology, BiologyExperimental Aging Research
A deficit in the ability to modify preexisting habits in a T-maze learning situation was observed, corroborating reports of increased perseveration in aged humans and nonhuman primates and raises the possibility that common neurological etiologies may exist for these behavioral deficits.
"Broad spectrum" antidepressants: is more better for the treatment of depression?
Interleukin-1 stimulates the beta-amyloid precursor protein promoter
- R. Donnelly, A. Friedhoff, B. Beer, A. Blume, M. Vitek
- BiologyCellular and molecular neurobiology
- 1 December 1990
It is shown here that this promoter is inducible in cultured cells by interleukin-1 (IL-1) in a transient assay system and that the HSE and AP-1 binding site are required for this inducibility.