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Phase I and pharmacokinetic study of hepatic arterial infusion with oxaliplatin in combination with folinic acid and 5-fluorouracil in patients with hepatic metastases from colorectal cancer.
BACKGROUND To determine dose-limiting toxicity (DLT), maximum tolerated dose (MTD), and pharmacokinetics (PK) of oxaliplatin administered as hepatic arterial infusion. PATIENTS AND METHODS PatientsExpand
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Synthesis of RNA by in vitro transcription.
In vitro transcription is a simple procedure that allows for template-directed synthesis of RNA molecules of any sequence from short oligonucleotides to those of several kilobases in μg to mgExpand
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Molecular modelling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes
Twin‐ribozyme introns contain a branching ribozyme (GIR1) followed by a homing endonuclease (HE) encoding sequence embedded in a peripheral domain of a group I splicing ribozyme (GIR2). GIR1Expand
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Hepatic arterial infusion with oxaliplatin, folinic acid, and 5-fluorouracil in patients with hepatic metastases from colorectal cancer: role of carcino-embryonic antigen in assessment of response.
BACKGROUND Therapy for patients with hepatic metastases from colorectal cancer (CRC) remains controversial and may be improved by regional oxaliplatin which proved to be effective when administeredExpand
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Accumulation of Stable Full-Length Circular Group I Intron RNAs during Heat-Shock
Group I introns in nuclear ribosomal RNA of eukaryotic microorganisms are processed by splicing or circularization. The latter results in formation of full-length circular introns without ligation ofExpand
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P-glycoprotein expression in patients with acute leukemia-clinical relevance.
P-glycoprotein (P-gp) is a crucial factor in the development of chemotherapy resistance in malignant disorders. Between 1989 and 1995, P-gp expression was studied in bone marrow blast cells of 322Expand
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Exploring RNA structure by integrative molecular modelling.
RNA molecular modelling is adequate to rapidly tackle the structure of RNA molecules. With new structured RNAs constituting a central class of cellular regulators discovered every year, the need forExpand
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131 Clinical relevance of P-glycoprotein-related resistance in patients with acute leukemia
P-glycoprotein (P-gp) is a crucial factor in the development of chemotherapy resistance in malignant disorders. Between 1989 and 1994 P-gp expression was prospectively studied in mononuclear boneExpand
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The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics
The ribosome is one of the major targets in the cell for clinically used antibiotics. However, the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our currentExpand
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Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance