• Publications
  • Influence
The action potential in mammalian central neurons
  • B. Bean
  • Biology, Medicine
    Nature Reviews Neuroscience
  • 1 June 2007
The action potential of the squid giant axon is formed by just two voltage-dependent conductances in the cell membrane, yet mammalian central neurons typically express more than a dozen different
P-type calcium channels blocked by the spider toxin ω-Aga-IVA
TLDR
A peptide toxin from funnel web spider venom, ω-Aga-IVA, is identified, which is a potent inhibitor of both calcium entry into rat brain synaptosomes and of 'P-type' calcium channels8 in rat Purkinje neurons, which will facilitate characterization of brain calcium channels resistant to existing channel blockers and may assist in the design of neuroprotective drugs.
Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
  • I. Raman, B. Bean
  • Chemistry, Medicine
    The Journal of Neuroscience
  • 15 June 1997
TLDR
The falling phase of an action potential is similar to voltage patterns that activate resurgent sodium current, and thus, resurgent Sodium current likely contributes to the formation of conglomerate action potentials in Purkinje neurons.
Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence
  • B. Bean
  • Chemistry, Medicine
    Nature
  • 13 July 1989
TLDR
It is found that inhibition of Ca2+ current is primarily due to a transmitter-induced change in the voltage-dependence with which channels are opened, but there is little or nochange in the number of functional channels activated by very large depolarizations.
Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
  • J. E. Huettner, B. Bean
  • Chemistry, Medicine
    Proceedings of the National Academy of Sciences…
  • 1 February 1988
TLDR
MK-801 greatly reduced the channel activity elicited by application of N-Me-D-Asp but did not significantly alter the predominant unitary conductance, and the mean channel open time was reduced by MK-801 in a dose-dependent manner.
Lidocaine block of cardiac sodium channels
TLDR
Results provide direct evidence for the “modulated-receptor hypothesis” of Hille ( 1977) and Hondeghem and Katzung (1977) and argue that use dependence at therapeutic levels reflects block of inactivated channels, rather than block of open channels.
Classes of calcium channels in vertebrate cells.
  • B. Bean
  • Chemistry, Medicine
    Annual review of physiology
  • 1989
TLDR
This article summarizes a recent wave of papers describing multiple Ca channel types in vertebrate cells, especially from comparative studies on invertebrates and receptor-operated Ca channels, or Ca channels of organelles.
Ionic Currents Underlying Spontaneous Action Potentials in Isolated Cerebellar Purkinje Neurons
  • I. Raman, B. Bean
  • Chemistry, Medicine
    The Journal of Neuroscience
  • 1 March 1999
TLDR
It is concluded that the spontaneous firing of Purkinje neuron cell bodies depends mainly on tetrodotoxin-sensitive sodium current flowing between spikes, which is promoted by large potassium currents that repolarize the cell rapidly and deactivate quickly, thus preventing strong hyperpolarization and restoring a high input resistance for subsequent depolarization.
Roles of Subthreshold Calcium Current and Sodium Current in Spontaneous Firing of Mouse Midbrain Dopamine Neurons
TLDR
The results support previous evidence for a major role of voltage-dependent calcium channels in driving pacemaking of midbrain dopamine neurons and suggest that multiple calcium channel types contribute to this function.
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