• Publications
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The action potential in mammalian central neurons
  • B. Bean
  • Medicine, Biology
  • Nature Reviews Neuroscience
  • 1 June 2007
The action potential of the squid giant axon is formed by just two voltage-dependent conductances in the cell membrane, yet mammalian central neurons typically express more than a dozen differentExpand
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P-type calcium channels blocked by the spider toxin ω-Aga-IVA
VOLTAGE-DEPENDENT calcium channels mediate calcium entry into neurons, which is crucial for many processes in the brain including synaptic transmission, dendritic spiking, gene expression and cellExpand
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P-type calcium channels in rat central and peripheral neurons
The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons (KD approximately 2 nM) but had no effect on identified T-type, L-type, or N-type currents in a variety ofExpand
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Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
Voltage-dependent sodium channels were studied in dissociated cerebellar Purkinje neurons from rats. In whole-cell recordings, a tetrodotoxin (TTX)-sensitive inward current was elicited when theExpand
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Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
  • J. E. Huettner, B. Bean
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 February 1988
Whole-cell and single-channel recording techniques were used to study the action of the anticonvulsant drug MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine maleate) onExpand
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Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence
  • B. Bean
  • Chemistry, Medicine
  • Nature
  • 13 July 1989
THE voltage-dependent calcium current of many neurons is depressed by transmitters such as noradrenaline1-3, GABA4-6, and kappa-opiate agonists7-12. This modulation probably constitutes a majorExpand
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Lidocaine block of cardiac sodium channels
Lidocaine block of cardiac sodium channels was studied in voltage-clamped rabbit purkinje fibers at drug concentrations ranging from 1 mM down to effective antiarrhythmic doses (5-20 μM).Expand
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Ionic Currents Underlying Spontaneous Action Potentials in Isolated Cerebellar Purkinje Neurons
Acutely dissociated cell bodies of mouse Purkinje neurons spontaneously fired action potentials at ∼50 Hz (25°C). To directly measure the ionic currents underlying spontaneous activity, weExpand
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Classes of calcium channels in vertebrate cells.
  • B. Bean
  • Biology, Medicine
  • Annual review of physiology
  • 1989
Voltage-dependent Ca channels help regulate a wide range of cellular func­ tions, including secretion, contraction, and excitability (56, 61, 73, 123). The diversity of Ca channels has long beenExpand
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Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
Most local anaesthetics used clinically are relatively hydrophobic molecules that gain access to their blocking site on the sodium channel by diffusing into or through the cell membrane. TheseExpand
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