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TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
- H. Skinner, V. Sandulache, +7 authors J. Myers
- Biology, Medicine
- Clinical Cancer Research
- 16 November 2011
Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this study, we use a… Expand
Eat and exercise during radiotherapy or chemoradiotherapy for pharyngeal cancers: use it or lose it.
- K. Hutcheson, M. Bhayani, +4 authors J. Lewin
- JAMA otolaryngology-- head & neck surgery
- 1 November 2013
IMPORTANCE Data support proactive swallowing therapy during radiotherapy (RT) or chemoradiotherapy (CRT) for pharyngeal cancers. The benefits of adherence to a regimen of swallowing exercises and… Expand
Association of Body Composition With Survival and Locoregional Control of Radiotherapy-Treated Head and Neck Squamous Cell Carcinoma.
IMPORTANCE Major weight loss is common in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy (RT). How baseline and posttreatment body composition affects outcome is… Expand
Cervix regression and motion during the course of external beam chemoradiation for cervical cancer.
- B. Beadle, A. Jhingran, M. Salehpour, M. Sam, R. Iyer, P. Eifel
- International journal of radiation oncology…
PURPOSE To evaluate the magnitude of cervix regression and motion during external beam chemoradiation for cervical cancer. METHODS AND MATERIALS Sixteen patients with cervical cancer underwent… Expand
Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
BACKGROUND The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and… Expand
The impact of pregnancy on breast cancer outcomes in women ≤35 years
Some evidence suggests that women with pregnancy‐associated breast cancers (PABC) have a worse outcome compared with historical controls. However, young age is a worse prognostic factor… Expand
Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations occurring in over two-thirds of cases, but the prognostic significance of these mutations remains… Expand
Beam path toxicity in candidate organs-at-risk: assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy.
- Esengul Kocak-Uzel, G. Gunn, +11 authors C. Fuller
- Radiotherapy and oncology : journal of the…
- 1 May 2014
BACKGROUND To investigate potential dose-response relationship between radiation-associated nausea and vomiting (RANV) reported during radiotherapy and candidate nausea/vomiting-associated regions of… Expand
The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer
We performed this study to define the incidence of radiographic retropharyngeal lymph node (RPLN) involvement in oropharyngeal cancer (OPC) and its impact on clinical outcomes, neither of which has… Expand
Radiotherapy for Head and Neck Cancers: Indications and Techniques