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Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline From the College of American Pathologists.
Context Human papillomavirus (HPV) is a major cause of oropharyngeal squamous cell carcinomas, and HPV (and/or surrogate marker p16) status has emerged as a prognostic marker that significantlyExpand
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TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this study, we use aExpand
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Association of Body Composition With Survival and Locoregional Control of Radiotherapy-Treated Head and Neck Squamous Cell Carcinoma.
IMPORTANCE Major weight loss is common in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy (RT). How baseline and posttreatment body composition affects outcome isExpand
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Eat and exercise during radiotherapy or chemoradiotherapy for pharyngeal cancers: use it or lose it.
IMPORTANCE Data support proactive swallowing therapy during radiotherapy (RT) or chemoradiotherapy (CRT) for pharyngeal cancers. The benefits of adherence to a regimen of swallowing exercises andExpand
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Cervix regression and motion during the course of external beam chemoradiation for cervical cancer.
PURPOSE To evaluate the magnitude of cervix regression and motion during external beam chemoradiation for cervical cancer. METHODS AND MATERIALS Sixteen patients with cervical cancer underwentExpand
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Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
BACKGROUND The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall andExpand
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The impact of pregnancy on breast cancer outcomes in women ≤35 years
Some evidence suggests that women with pregnancy‐associated breast cancers (PABC) have a worse outcome compared with historical controls. However, young age is a worse prognostic factorExpand
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Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations occurring in over two-thirds of cases, but the prognostic significance of these mutations remainsExpand
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Structural bases of stability-function tradeoffs in enzymes.
The structures of enzymes reflect two tendencies that appear opposed. On one hand, they fold into compact, stable structures; on the other hand, they bind a ligand and catalyze a reaction. To beExpand
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Structural Basis for Imipenem Inhibition of Class C β-Lactamases
ABSTRACT To determine how imipenem inhibits the class C β-lactamase AmpC, the X-ray crystal structure of the acyl-enzyme complex was determined to a resolution of 1.80 Å. In the complex, the lactamExpand
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