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Guidelines for the use and interpretation of assays for monitoring autophagy
- D. Klionsky, F. Abdalla, +498 authors Shengzhou or sheng-zhou wu
- Medicine, Biology
- 1 April 2012
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. Expand
Metallothioneins in human tumors and potential roles in carcinogenesis.
The evidence supporting a role for MT in both intrinsic and acquired drug resistance is critically evaluated and it is difficult to conclude that MT is a more crucial factor than others. Expand
Phyllodes tumors of the breast: the role of pathologic parameters.
- P. Tan, Thiyagarajan Jayabaskar, +6 authors B. Bay
- American journal of clinical pathology
- 1 April 2005
Multivariate analysis revealed that independent predictors of recurrence were pseudoangiomatous stromal hyperplasia (PASH) and margin status, whereby the presence of PASH and complete or negative margins reduced recurrence hazards by 51.3% and 51.7% respectively. Expand
Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution.
This study proposes a cost-effective composite consisting of a nanofibrous scaffold directly electrospun onto a polyurethane dressing (Tegaderm, 3M Medical) - which it is called the Tegaderm-nanofiber (TG-NF) construct - for dermal wound healing. Expand
Nanoparticle-induced pulmonary toxicity
- J. J. Li, S. Muralikrishnan, C. Ng, Lin-Yue Lanry Yung, B. Bay
- Experimental biology and medicine
- 1 September 2010
Different aspects of lung toxicity resulting from NP exposure are highlighted, such as generation of oxidative stress, DNA damage and inflammation leading to fibrosis and pneumoconiosis, and the underlying mechanisms causing pulmonary toxicity. Expand
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
- R. Sinha, S. You, +10 authors P. Yen
- Medicine, Biology
- The Journal of clinical investigation
- 2 July 2012
It is reported that TH stimulation of fatty acid β-oxidation is coupled with induction of hepatic autophagy to deliver fatty acids to mitochondria in cell culture and in vivo and that THs can regulate lipid homeostasis via Autophagy. Expand
Prognostic Significance of Glutathione S-Transferase-Pi in Invasive Breast Cancer
The findings indicate that GST- pi–positive tumors are more aggressive and have a poorer prognosis than do corresponding GST-pi–negative breast cancers. Expand
Autophagy and oxidative stress associated with gold nanoparticles.
- J. J. Li, Deny Hartono, C. Ong, B. Bay, L. Y. Yung
- Materials Science, Medicine
- 1 August 2010
It is shown that AuNPs, which were taken up by MRC-5 human lung fibroblasts in vitro, induce autophagy concomitant with oxidative stress, which may be a cellular defence mechanism against oxidative stress toxicity. Expand
Parkin Enhances the Expression of Cyclin-dependent Kinase 6 and Negatively Regulates the Proliferation of Breast Cancer Cells*
- Shiam-Peng Tay, Calvin W S Yeo, +11 authors K. Lim
- Medicine, Biology
- The Journal of Biological Chemistry
- 14 July 2010
It is found that ectopic parkin expression in parkin-deficient breast cancer cells mitigates their proliferation rate both in vitro and in vivo, as well as reduces the capacity of these cells to migrate. Expand
Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice
It is demonstrated that caffeine reduces intrahepatic lipid content and stimulates β‐oxidation in hepatic cells and liver by an autophagy‐lysosomal pathway and is a potent stimulator of hepatic autophagic flux. Expand