• Publications
  • Influence
Synthesis, characterization, and biodistribution of multiple 89Zr-labeled pore-expanded mesoporous silica nanoparticles for PET.
TLDR
The results suggest that (89)Zr-DFO-MSNs are promising PET imaging agents for long-term in vivo imaging. Expand
Synthesis, Radiolabelling and In Vitro Characterization of the Gallium-68-, Yttrium-90- and Lutetium-177-Labelled PSMA Ligand, CHX-A''-DTPA-DUPA-Pep
TLDR
The synthesis of a new PSMA ligand, CHX-A''-DTPA-DUPA-Pep, the subsequent labelling with Ga-68, Lu-177 and Y-90 and the first in vitro characterization are described, indicating high biological activities towards PSMA. Expand
A novel type of mutation in the cysteine rich domain of the RET receptor causes ligand independent activation
TLDR
It is demonstrated that an additional cysteine causes a ligand independent dimerization of the RET receptor in transfected NIH3T3 cells, which results in an activation of the intracellular tyrosine kinase. Expand
Synthesis and labelling of Df-DUPA-Pep with gallium-68 and zirconium-89 as new PSMA ligands
Prostate-specific membrane antigen (PSMA) is a cell surface protein that is overexpressed in prostate cancer. Due to the specificity of expression of PSMA, numerous urea-based ligands have beenExpand
Radiofluorination of PSMA-HBED via Al18F2+ Chelation and Biological Evaluations In Vitro
TLDR
An efficient and one-pot method for the radiosynthesis of [Al18F]PSMA-HBED was developed and the labeled peptide revealed serum stability for 4 h as well as a promising binding coefficient (KD) value of 10.3 ± 2.2 nM in cell experiments with PSMA-positive LNCaP C4-2 cells. Expand
Targeting the hinge glycine flip and the activation loop: novel approach to potent p38α inhibitors.
TLDR
Dibenzepinones, dibenzoxepines, and benzosuberones are reported as p38α MAP kinase inhibitors, and interactions with the DFG-motif in the in-conformation could be observed by protein X-ray crystallography. Expand
Comment on Afshar-Oromieh et al.: PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions
TLDR
In a study comprising 37 patients a discussion of 42 patients in the text needs clarification, the assumption that a prostate involved with prostate cancer and treated with local radiation therapy and androgen deprivation therapy can be regarded as a ‘normal prostate’ is not followed. Expand
Quantitative and correlative biodistribution analysis of 89Zr-labeled mesoporous silica nanoparticles intravenously injected into tumor-bearing mice.
TLDR
The biodistribution of 89Zr-labeled mesoporous silica nanoparticles was evaluated in detail using a prostate cancer mouse model bearing LNCaP C4-2 and PC-3 tumor xenografts with focus on passive targeting to highlight the importance of correlative analyses in order to evaluate the organ accumulation of particles. Expand
Metabolically stable dibenzo[b,e]oxepin-11(6H)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood.
TLDR
Five series of metabolically stable disubstituted dibenzo[b,e]oxepin-11(6H)-ones were synthesized and tested in a p38α enzyme assay for their inhibition of tumor necrosis factor-α release in human whole blood and it has been shown that the additional introduction of hydrophilic residues at position 9 leads to a substantial improvement of the inhibitory potency and metabolic stability. Expand
3-(2,4-Difluoroanilino)-9-nitrodibenzo[b,e]oxepin-11(6H)-one
TLDR
In the title compound, C20H12F2N2O4, the two benzene rings of the tricyclic unit are oriented at a dihedral angle of 30.6 (1)° and the 2,4-difluoroanilino residue is oriented with respect to the phenoxy ring. Expand
...
1
2
3
...