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Regulation of the endothelin system by shear stress in human endothelial cells
- H. Morawietz, R. Talanow, +5 authors J. Holtz
- Chemistry, Medicine
- The Journal of physiology
- 1 June 2000
1 In this study, the effect of shear stress on the expression of genes of the human endothelin‐1 system was examined. Primary cultures of human umbilical vein endothelial cells (HUVEC) were exposed… Expand
Contribution of myocyte apoptosis to myocardial infarction?
Continuously ongoing loss of cardiac myocytes by apoptosis, resulting from myocyte stretch due to hemodynamic overload, has been hypothesized as contributing to the progression of myocardial… Expand
Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer
- H. Hofmann, A. Simm, A. Hammer, R. Silber, B. Bartling
- Biology, Medicine
- Journal of Cancer Research and Clinical Oncology
- 5 September 2002
Abstract Purpose. Apoptotic cell death contributes to the regulation of tumour regression but can be prevented by proteins of the IAP family. Although survivin can be identified as tumour-specific… Expand
Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma.
- B. Bartling, H. Hofmann, B. Weigle, R. Silber, A. Simm
- Biology, Medicine
- 11 November 2004
The receptor for advanced glycation end-products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily. Several ligands binding to RAGE have been identified, including amphoterin.… Expand
Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma.
Expression profiling by gene microarray techniques have been developed to predict malignant tissue but there are no experiences with the application of antibody arrays to identify malignancy-related… Expand
Potential biomarkers of ageing
- A. Simm, N. Nass, B. Bartling, B. Hofmann, R. Silber, A. Navarrete Santos
- Biological chemistry
- 1 March 2008
Abstract Life span in individual humans is very heterogeneous. Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual. There… Expand
S100A2-S100P expression profile and diagnosis of non-small cell lung carcinoma: impairment by advanced tumour stages and neoadjuvant chemotherapy.
- B. Bartling, G. Rehbein, W. Schmitt, H. Hofmann, R. Silber, A. Simm
- European journal of cancer
- 1 September 2007
Early and correct diagnosis of non-small cell lung carcinoma (NSCLC) is essential for the choice of an appropriate anti-cancer therapy. Besides the histopathological diagnosis, molecular profiling by… Expand
Differential impact of fibroblasts on the efficient cell death of lung cancer cells induced by paclitaxel and cisplatin
The efficient treatment of lung carcinomas with chemotherapeutics still poses a challenge for anti-cancer therapy. Since stromal cells of the tumor may alter the responsiveness of tumor cells to… Expand
Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure.
BACKGROUND In patients with end-stage heart failure, characterized by an increased susceptibility to cardiomyocyte apoptosis and a labile cardiomyocyte calcium homeostasis, a ventricular assist… Expand
Discrimination of human lung neoplasm from normal lung by two target genes.
- H. Hofmann, G. Hansen, S. Burdach, B. Bartling, R. Silber, A. Simm
- American journal of respiratory and critical care…
- 1 September 2004
Simple tools for discrimination of lung tissues can be useful in a fast machine-aided diagnosis, for example, by tumor-specific microarrays. We demonstrate that an easy ratio technique, based on the… Expand