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Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration
The regenerative capacity of the peripheral nervous system declines with age. Why this occurs, however, is unknown. We demonstrate that 24-month-old mice exhibit an impairment of functional recoveryExpand
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The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination
Inhibitors associated with CNS myelin are thought to be important in the failure of axons to regenerate after spinal cord injury and in other neurodegenerative disorders. Here we show that targetingExpand
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Enhanced synaptic connectivity and epilepsy in C1q knockout mice
Excessive CNS synapses are eliminated during development to establish mature patterns of neuronal connectivity. A complement cascade protein, C1q, is involved in this process. Mice deficient in C1qExpand
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Open Access
Identification of a Gene Regulatory Network Necessary for the Initiation of Oligodendrocyte Differentiation
Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes requires extensive changes in gene expression, which are partly mediated by post-translational modifications ofExpand
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Thrombospondin-4 Contributes to Spinal Sensitization and Neuropathic Pain States
Neuropathic pain is a common cause of pain after nerve injury, but its molecular basis is poorly understood. In a post-gene chip microarray effort to identify new target genes contributing toExpand
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Open Access
Central Mechanisms Mediating Thrombospondin-4-induced Pain States*
Peripheral nerve injury induces increased expression of thrombospondin-4 (TSP4) in spinal cord and dorsal root ganglia that contributes to neuropathic pain states through unknown mechanisms. Here, weExpand
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Open Access
Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit α2δ-1
The alpha2delta-1 subunit (α2δ-1) of voltage-gated calcium channels is a receptor for astrocyte-secreted thrombospondins that promote developmental synaptogenesis. Alpha2delta-1 receptors areExpand
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Oral lichenoid reactions associated with anti‐PD‐1/PD‐L1 therapies: clinicopathological findings
Immune checkpoint inhibitors targeting the programmed cell death receptor-1 (PD-1) or its ligand (PD-L1) show broad activity across different tumor types and currently represent one of the keystonesExpand
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Laboratory life: Scientists of the world speak up for equality
Eight experts give their prescriptions for measures that will help to close the gender gap in national from China to Sweden
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Not just Salk
In her Science Insider News Story “Salk Institute hit with discrimination lawsuit by third female scientist” (20 July, ) M. Wadman reports that three of the four senior women scientists at the SalkExpand
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