• Publications
  • Influence
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
TLDR
These findings call into question the concept of a “glial” cell class as the gene profiles of astrocyte and oligodendrocytes are as dissimilar to each other as they are to neurons, for better understanding of neural development, function, and disease. Expand
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
TLDR
The authors' data provide clues as to how neurons and astrocytes differ in their ability to dynamically regulate glycolytic flux and lactate generation attributable to unique splicing of PKM2, the gene encoding the glycoleytic enzyme pyruvate kinase. Expand
Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis
TLDR
These studies identify TSPs as CNS synaptogenic proteins, provide evidence that astrocytes are important contributors to synaptogenesis within the developing CNS, and suggest that TSP-1 and -2 act as a permissive switch that times CNSsynaptogenesis by enabling neuronal molecules to assemble into synapses within a specific window of CNS development. Expand
Genomic Analysis of Reactive Astrogliosis
TLDR
The findings provide transcriptome databases for two subtypes of reactive astrocytes that will be highly useful in generating new and testable hypotheses of their function, as well as for providing new markers to detect different types of reactiveAstrocyte reactive gliosis in human neurological diseases. Expand
Neurotoxic reactive astrocytes are induced by activated microglia
TLDR
It is shown that activated microglia induce A1 astrocytes by secreting Il-1α, TNF and C1q, and that these cytokines together are necessary and sufficient to induce A2 astroCytes, which are abundant in various human neurodegenerative diseases. Expand
Pericytes are required for blood–brain barrier integrity during embryogenesis
TLDR
Pericytes regulate functional aspects of the blood–brain barrier, including the formation of tight junctions and vesicle trafficking in CNS endothelial cells, but inhibit the expression of molecules that increase vascular permeability and CNS immune cell infiltration. Expand
The Classical Complement Cascade Mediates CNS Synapse Elimination
TLDR
It is shown that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response to immature astrocytes and is localized to synapses throughout the postnatal CNS and retina, supporting a model in which unwanted synapses are tagged by complement for elimination and suggesting that complement-mediated synapse elimination may become aberrantly reactivated in neurodegenerative disease. Expand
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
TLDR
It is shown that microglia engulf presynaptic inputs during peak retinogeniculate pruning and that engulfment is dependent upon neural activity and themicroglia-specific phagocytic signaling pathway, complement receptor 3(CR3)/C3. Expand
The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease
  • B. Barres
  • Psychology, Medicine
  • Neuron
  • 6 November 2008
TLDR
It is argued that until the roles of nonneuronal cells are more fully understood and considered, neurobiology as a whole will progress only slowly. Expand
New tools for studying microglia in the mouse and human CNS
TLDR
Transmembrane protein 119 (Tmem119), a cell-surface protein of unknown function, is identified as a highly expressed microglia-specific marker in both mouse and human, which will greatly facilitate understanding of microglial function in health and disease. Expand
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